The Landscape of Interactions between Hypoxia-Inducible Factors and Reactive Oxygen Species in the Gastrointestinal Tract

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成果类型：

期刊论文

作者：

Shao, Yirui;Wang, Kexing;Xiong, Xia*;Liu, Hongnan;Zhou, Jian;...

通讯作者：

Xiong, Xia

作者机构：

[Zhou, Jian; Liu, Hongnan; Tan, Zhiliang; Huang, Ruilin; Xiong, Xia; Qi, Ming; Yin, Yulong; Shao, Yirui] Chinese Acad Sci, Hunan Prov Key Lab Anim Nutr Physiol & Metab Proc, Natl Engn Lab Pollut Control & Waste Utilizat Liv, Key Lab Agroecol Proc Subtrop Reg,Inst Subtrop Ag, Changsha 410125, Hunan, Peoples R China.

[Zhou, Jian; Qi, Ming; Yin, Yulong; Shao, Yirui] Univ Chinese Acad Sci, Beijing 100008, Peoples R China.

[Wang, Kexing] Hunan Normal Univ, Coll Life Sci, Lab Anim Nutr & Human Hlth, Changsha 410081, Peoples R China.

[Zou, Lijun] Hunan First Normal Univ, Lab Basic Biol, Changsha 410205, Peoples R China.

[Liu, Gang] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.

通讯机构：

[Xiong, Xia] C

Chinese Acad Sci, Hunan Prov Key Lab Anim Nutr Physiol & Metab Proc, Natl Engn Lab Pollut Control & Waste Utilizat Liv, Key Lab Agroecol Proc Subtrop Reg,Inst Subtrop Ag, Changsha 410125, Hunan, Peoples R China.

语种：

英文

期刊：

Oxidative Medicine and Cellular Longevity

ISSN：

1942-0900

年：

2021

卷：

2021

DOI：

10.1155/2021/8893663

基金类别：

Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2018JJ1028]; Innovation Team of Key areas of the Ministry of Science and Technology; National Key Research and Development Program of China [2018YFD0501101]; Science and Technology Program of Changsha [kq1907074]; Science and Technology Leadership Program of Hunan Province [2019RS3021]; Research Foundation of Education Bureau of Hunan Province, China [18B476]

机构署名：

本校为其他机构

院系归属：

生物科学技术学院

摘要：

The gastrointestinal tract (GT) is the major organ involved in digestion, absorption, and immunity, which is prone to oxidative destruction by high levels of reactive oxygen species (ROS) from luminal oxidants, such as food, drugs, and pathogens. Excessive ROS will lead to oxidative stresses and disrupt essential biomolecules, which also act as cellular signaling molecules in response to growth factors, hormones, and oxygen tension changes. Hypoxia-inducible factors (HIFs) are critical regulators mediating responses to cellular oxygen tension changes, which are also involved in energy metaboli...

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The Landscape of Interactions between Hypoxia-Inducible Factors and Reactive Oxygen Species in the Gastrointestinal Tract

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