Applications of Artificial Intelligence in Drug Repurposing

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wan, Zhaoman;Sun, Xinran;Li, Yi;Chu, Tianyao;Hao, Xueyu;...

通讯作者：

Zhang, P;Cao, Y

作者机构：

[Wan, Zhaoman] Chinese Acad Med Sci & Peking Union Med Coll, Suzhou Inst Syst Med, State Key Lab Common Mech Res Major Dis, Suzhou 215123, Jiangsu, Peoples R China.

[Sun, Xinran] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Beijing 100193, Peoples R China.

[Li, Yi] Hunan Agr Univ, Coll Plant Protect, Changsha 410128, Hunan, Peoples R China.

[Chu, Tianyao; Zhang, Peng; Zhang, P; Hao, Xueyu] Capital Med Univ, Beijing Childrens Hosp, Rare Dis Ctr, Natl Ctr Childrens Hlth,Beijing Pediat Res Inst,Be, Beijing 100045, Peoples R China.

[Cao, Y; Cao, Yang] Sichuan Univ, Coll Life Sci, Chengdu 610041, Sichuan, Peoples R China.

通讯机构：

[Cao, Y ] S

[Zhang, P ] C

Capital Med Univ, Beijing Childrens Hosp, Rare Dis Ctr, Natl Ctr Childrens Hlth,Beijing Pediat Res Inst,Be, Beijing 100045, Peoples R China.

Sichuan Univ, Coll Life Sci, Chengdu 610041, Sichuan, Peoples R China.

语种：

英文

关键词：

artificial intelligence;drug repurposing;drug-response prediction;machine learning models;personalized medicine

期刊：

Advanced Science

ISSN：

2198-3844

年：

2025

卷：

期：

页码：

e2411325

DOI：

10.1002/advs.202411325

基金类别：

National Key R&D Program of China; Reform and Development of Beijing Municipal Health Commission; National Natural Science Foundation of China [32470696]; [2023YFC2507000]

机构署名：

本校为其他机构

院系归属：

植物保护学院

摘要：

Drug repurposing identifies new therapeutic uses for the existing drugs originally developed for different indications, aiming at capitalizing on the established safety and efficacy profiles of known drugs. Thus, it is beneficial to bypass of early stages of drug development, and to reduction of the time and cost associated with bringing new therapies to market. Traditional experimental methods are often time-consuming and expensive, making artificial intelligence (AI) a promising alternative due to its lower cost, computational advantages, and ability to uncover hidden patterns. This review f...

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