期刊论文

Tian, Yun;Liu, HH

英文

Biotechnology Letters

0141-5492

2025

47

3

1-13

10.1007/s10529-025-03591-7

This work was supported by the National Natural Science Foundation of China (No. 21808052), the Training Program for Excellent Young Innovators of Changsha (kq2406009), The Science and Technology Innovation Program of Hunan Province (2022RC1170), the Natural Science Foundation of Changsha (No. kq2208077), the Hunan Provincial Natural Science Foundation of China (2022 JJ50022), the Foundation of State Key Laboratory of Utilization of Woody Oil Resource (GZKF202119), the Hunan Science and Technology Talent Lifting Project-Young and Middle-Aged Excellent Science and Technology Talent Training Program (2023 TJ-Z04), the Science and Technology Innovation Program of Forestry in Hunan Province (XLKY202310), Postgraduate Scientific Research Innovation Project of Hunan Agricultural University (2023XC094).

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Squalene is a triterpene with various biological applications. However, the conventioneer squalene industry is limited by complex extraction processes and environmental pollution, necessitating an environmentally sustainable solution to the increasing demand for squalene. Microbial synthesis is a potentially green and efficient method of producing squalene. Acetyl-CoA is a key precursor of squalene. First, we investigated the effects of enhanced acetyl-CoA supply on squalene production, lipid content, and total fatty acid content in Yarrowia lipolytica. Then, strain YLACLH2 with a squalene pro...