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Elucidation of the 1-phenethylisoquinoline pathway from an endemic conifer Cephalotaxus hainanensis

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成果类型:
期刊论文
作者:
Qiao, Fei;He, Yuedong;Zhang, Yuhao;Jiang, Xuefei;Cong, Hanqing;...
通讯作者:
Fei Qiao<&wdkj&>Yuedong He<&wdkj&>Yuhao Zhang<&wdkj&>Huapeng Sun<&wdkj&>Yibei Xiao<&wdkj&>Yucheng Zhao
作者机构:
[Qiao, Fei; He, Yuedong; Cong, Hanqing; Sun, Huapeng] Key Laboratory of Crop Gene Resources and Germplasm Enhancement in Southern China,ministry of Agriculture
[Qiao, Fei; He, Yuedong; Cong, Hanqing; Sun, Huapeng] Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
[He, Yuedong] College of Horticulture, Hunan Agricultural University, Changsha 410128, China
[Zhang, Yuhao; Zhao, Yucheng] Department of Resources Science of Traditional Chinese Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China
[Jiang, Xuefei; Wang, Zhiming] Hainan Key Laboratory of Sustainable Utilization of Tropical Bioresources, College of Horticulture, Hainan University, Haikou 570228, China
通讯机构:
[Fei Qiao; Yuedong He; Huapeng Sun] K
[Yuhao Zhang; Yibei Xiao; Yucheng Zhao] D
Key Laboratory of Crop Gene Resources and Germplasm Enhancement in Southern China, ministry of Agriculture
Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China<&wdkj&>College of Horticulture, Hunan Agricultural University, Changsha 410128, China<&wdkj&>Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China<&wdkj&>State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China<&wdkj&>Key Laboratory of Crop Gene Resources and Germplasm Enhancement in Southern China, ministry of Agriculture
Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China<&wdkj&>Department of Resources Science of Traditional Chinese Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China
语种:
英文
关键词:
1-phenethylisoquinoline;C. hainanensis;ChPSS;phenylethylisoquinoline alkaloids
期刊:
Proceedings of the National Academy of Sciences of the United States of America
ISSN:
0027-8424
年:
2023
卷:
120
期:
1
页码:
e2209339120
机构署名:
本校为通讯机构
院系归属:
园艺园林学院
摘要:
Cephalotaxines harbor great medical potential, but their natural source, the endemic conifer Cephalotaxus is highly endangered, creating a conflict between biotechnological valorization and preservation of biodiversity. Here, we construct the whole biosynthetic pathway to the 1-phenethylisoquinoline scaffold, as first committed compound for phenylethylisoquinoline alkaloids (PIAs), combining metabolic modeling, and transcriptomemining ofCephalotaxushainanensis to infer the biosynthesis for PIA precursor. We identify a novel protein, ChPSS, driving the Pictet-Spengler condensation and show that...

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