Protective autophagy alleviates neurotoxin-gelsenicine induced apoptosis through PERK signaling pathway in Neuro-2a cells

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成果类型：

期刊论文

作者：

Li, Yujuan;Hu, Peipei;Zhang, Zhiqiang;Yuan, Zhihang;Yang, Kun;...

通讯作者：

Kun Yang

作者机构：

[Li, Yujuan; Sun, Zhiliang; Yuan, Zhihang] Hunan Agr Univ, Hunan Engn Technol Res Ctr Vet Drugs, Changsha 410128, Hunan, Peoples R China.

[Li, Yujuan] Xiangnan Univ, Dept Basic Med, Chenzhou 423000, Hunan, Peoples R China.

[Li, Yujuan; Sun, Zhiliang; Yuan, Zhihang] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

[Zhang, Zhiqiang; Yang, Kun; Hu, Peipei] Henan Univ Anim Husb & Econ, Coll Anim Med, Zhengzhou 400045, Henan, Peoples R China.

[Sun, Zhiliang] Hunan Agr Univ, Natl Res Ctr Engn & Technol Utilizat Bot Funct In, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Kun Yang] C

College of Animal Medicine, Henan University of Animal Husbandry and Economics, Zhengzhou, Henan 400045, China

语种：

英文

关键词：

Alkaloid;Apoptosis;Autophagy;Gelsemium elegans Benth.;Gelsenicine;Neurotoxicity

期刊：

Toxicology

ISSN：

0300-483X

年：

2022

卷：

474

页码：

153210

DOI：

10.1016/j.tox.2022.153210

基金类别：

National Key Research and Development Programme of China [2017YFD0501403]; National Natural Science Foundation of China [32172919]; Doctoral Scientific Research Foundation of Henan University of Animal Husbandry and Economy [M4030068]

机构署名：

本校为第一机构

院系归属：

园艺园林学院

动物医学院

摘要：

Gelsemium elegans Benth. (G. elegans) showed significant biological activities, but it has the side effects of neurotoxicity, predominantly in the form of respiratory depression. Gelsenicine is the main toxic constituent of G. elegans which is highly neurotoxic to humans and animals. Although the acute neurotoxicity of gelsenicine has been widely reported, but neurotoxicity mechanisms have not been elucidated and its direct effect on nerve cells remains poorly characterized. In this study, Neuro-2a cells were used to be our object of study for ...

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Protective autophagy alleviates neurotoxin-gelsenicine induced apoptosis through PERK signaling pathway in Neuro-2a cells

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