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L-Theanine regulates lipid metabolism by modulating gut microbiota and bile acid metabolism

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成果类型:
期刊论文
作者:
Xu, Wei;Kong, Yingying;Zhang, Tuo;Gong, Zhihua;Xiao, Wenjun
通讯作者:
Wenjun Xiao<&wdkj&>Wenjun Xiao Wenjun Xiao Wenjun Xiao
作者机构:
[Gong, Zhihua; Kong, Yingying; Zhang, Tuo; Xiao, Wenjun; Xu, Wei] Hunan Agr Univ, Key Lab Tea Sci, Minist Educ, Changsha 410128, Hunan, Peoples R China.
[Gong, Zhihua; Kong, Yingying; Zhang, Tuo; Xiao, Wenjun; Xu, Wei] Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Bot Funct Ingr, Changsha, Peoples R China.
[Gong, Zhihua; Kong, Yingying; Zhang, Tuo; Xiao, Wenjun; Xu, Wei] Educ Minist Utilizat Bot Funct Ingredients, Coinnovat Ctr, Changsha, Peoples R China.
通讯机构:
[Wenjun Xiao; Wenjun Xiao Wenjun Xiao Wenjun Xiao] K
Key Lab of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha, China<&wdkj&>National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha, China<&wdkj&>Co-Innovation Center of Education Ministry for Utilization of Botanical Functional Ingredients, Changsha, China
语种:
英文
关键词:
l-theanine;nutritional intervention;bile acids;lipid metabolism
期刊:
Journal of the Science of Food and Agriculture
ISSN:
0022-5142
年:
2023
卷:
103
期:
3
页码:
1283-1293
基金类别:
National Natural Science Foundation of China [31871804]; Natural Science Foundation Project of Hunan Province, China [2020JJ4036]; Key R&D Program of Hunan Province [2020NK2030]
机构署名:
本校为第一机构
院系归属:
园艺园林学院
摘要:
BACKGROUND: l-Theanine (LTA) is a biologically active ingredient in tea that shows great potential for regulating lipid metabolism. Bile acids (BA), an important end-product of cholesterol catabolism, participate in the regulation of lipid metabolism and gut microbiota. Here, we investigated the effect of LTA on lipid metabolism and the mechanism by which it regulates BA metabolism and gut microbiota. Male BALB/c mice were treated with LTA for 28 days. RESULTS: Daily LTA doses of 100 and 300 mg kg(-1) d(-1) altered the gut microbiota in mice...

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