C11orf53 Promotes the Progression of Small Cell Lung Cancer by Regulating Glucose Metabolism

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成果类型：

期刊论文

作者：

Liao, Shuxian;Zhang, Mengxia;Li, Shengfen;Gao, Yuan;Huang, Ruilei;...

通讯作者：

Ning, Qian;Tang, SS;Ning, Q

作者机构：

[Gao, Yuan; Tang, Shengsong; Zhao, Xuhong; Zhang, Mengxia; Liao, Shuxian; Li, Shengfen; Ning, Qian; Huang, Ruilei] Hunan Univ Med, Biomed Res Inst, Hunan Prov Key Lab Antibody Based Drug & Intellige, Huaihua, Peoples R China.

[Tang, Shengsong; Liao, Shuxian; Li, Shengfen; Ning, Qian] Univ South China, Inst Pharm & Pharmacol, Hengyang, Peoples R China.

[Tang, Shengsong; Zhang, Mengxia] Hunan Univ Chinese Med, Dept Histol & Embryol, Changsha, Peoples R China.

[Gao, Yuan; Tang, Shengsong] Ningxia Med Univ, Dept Pharmacol, Yinchuan, Peoples R China.

[Ning, Qian] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha, Peoples R China.

通讯机构：

[Tang, SS ; Ning, Q ; Ning, Q] H

Hunan Univ Med, Biomed Res Inst, Hunan Prov Key Lab Antibody Based Drug & Intellige, Huaihua, Peoples R China.

Univ South China, Inst Pharm & Pharmacol, Hengyang, Peoples R China.

Hunan Univ Chinese Med, Dept Histol & Embryol, Changsha, Peoples R China.

Ningxia Med Univ, Dept Pharmacol, Yinchuan, Peoples R China.

语种：

英文

关键词：

C11orf53;glycolysis;metabolism;NCI-H526;small cell lung cancer

期刊：

Chemistry & Biodiversity

ISSN：

1612-1872

年：

2025

页码：

e01157

DOI：

10.1002/cbdv.202501157

基金类别：

Shuxian Liao and Mengxia Zhang contributed equally to this work. : This study was supported by the Hunan Provincial Science and Technology Plan Key Projects of China [2017SK2183], Natural Science Foundation of Hunan Province of China [2019JJ50416; 2024JJ7324], Scientific Research Fund of Hunan Provincial Education Department [23B1042], and the Scientific Research Project of Hunan Provincial Health Commission [202113022028].

机构署名：

本校为通讯机构

院系归属：

生物科学技术学院

摘要：

Small cell lung cancer (SCLC), the most malignant subtype of lung cancer, is a major cause of death among lung cancer patients. Drug resistance, high recurrence, and limitations of surgery are all obstacles to SCLC treatment. Consequently, clarifying the underlying mechanism of SCLC progression and identifying potential targets for therapeutic intervention are of paramount significance for improving the clinical outcomes of SCLC patients. C11orf53 has been demonstrated to play a crucial role in the NCI-H526 cell activity. However, few studies have focused on how C11orf53 affects the activity o...

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C11orf53 Promotes the Progression of Small Cell Lung Cancer by Regulating Glucose Metabolism

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