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Role of ADAR1 on Proliferation and Differentiation in Porcine Preadipocytes

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成果类型:
期刊论文
作者:
Yang, Menghuan;Jiang, Jun;Ren, Ruimin;Gao, Ning;He, Jun*;...
通讯作者:
He, Jun;Zhang, YB
作者机构:
[Gao, Ning; Ren, Ruimin; He, Jun; Yang, Menghuan; Zhang, Yuebo; He, J; Jiang, Jun] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Peoples R China.
[Gao, Ning; Ren, Ruimin; He, Jun; Yang, Menghuan; Zhang, Yuebo; He, J; Jiang, Jun] Minist Agr & Rural Affairs, Key Lab Livestock & Poultry Resources Pig Evaluat, Changsha 410128, Peoples R China.
通讯机构:
[Zhang, YB ; He, J] H
Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Peoples R China.
Minist Agr & Rural Affairs, Key Lab Livestock & Poultry Resources Pig Evaluat, Changsha 410128, Peoples R China.
语种:
英文
关键词:
ADAR1;preadipocyte;proliferation;differentiation;RNA-seq
期刊:
ANIMALS
ISSN:
2076-2615
年:
2024
卷:
14
期:
8
页码:
1201-
基金类别:
This research was funded by the Excellent Youth Project of Hunan Provincial Department of Education (22B0209), Special Fund for the Construction of Innovative Provinces in Hunan (2021NK1009) and Hunan Province Science and Technology Talent Lifting Project (2022TJ-Q15).
机构署名:
本校为第一且通讯机构
院系归属:
动物科学技术学院
摘要:
Simple Summary Fat deposition is essential for the productivity of livestock farming and is also of considerable importance for maintaining human health. Previous studies have provided a clue to explore the involvement of adenosine deaminase acting on RNA 1 (ADAR1) in adipogenesis. In this study, we confirmed that ADAR1 enhances the proliferation and suppresses the differentiation and apoptosis of porcine preadipocytes through over-expression and knockdown approaches. We also identify the genes and pathways that ADAR1 may affect in the regulation of preadipocyte proliferation. The findings pro...

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