版权说明 操作指南
首页 > 成果 > 详情

Absorption and Transport Mechanism of Red Meat-Derived N-glycolylneuraminic Acid and Its Damage to Intestinal Barrier Function through the NF-κB Signaling Pathway

认领
导出
Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
He, Enqi;Quan, Wei;Luo, Jie;Liu, Chuxin;Zheng, Wanting;...
通讯作者:
Qingwu Shen
作者机构:
[Shen, Qingwu; He, Enqi; Liu, Chuxin; Zheng, Wanting; Luo, Jie; Quan, Wei] Hunan Agr Univ, Sch Food Sci & Technol, Changsha 410128, Peoples R China.
通讯机构:
[Qingwu Shen] S
School of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China<&wdkj&>Author to whom correspondence should be addressed.
语种:
英文
关键词:
Neu5Gc;transport mechanisms;intestinal barrier function;NF-kappa B;cytotoxicology
期刊:
TOXINS
ISSN:
2072-6651
年:
2023
卷:
15
期:
2
页码:
132-
基金类别:
Conceptualization, E.H. and Q.S.; data curation, J.L. and W.Z.; funding acquisition, Q.S.; methodology, E.H., W.Q. and C.L.; project administration, E.H. and Q.S.; software, E.H., J.L., C.L. and W.Z.; validation, E.H., C.L., and Q.S.; writing—original draft, E.H. and W.Q.; writing—review and editing, E.H., W.Q., J.L. and Q.S. All authors have read and agreed to the published version of the manuscript. This research was funded by the National Nature Science Foundation of China, grant number 31771992.
机构署名:
本校为第一机构
院系归属:
食品科学技术学院
摘要:
N-glycolylneuraminic acid (Neu5Gc) is a specific factor in red meat that induces intestinal disease. Our aim was to investigate the effect of Neu5Gc on the intestinal barrier as well as its mechanism of endocytosis and exocytosis. Ten specific inhibitors were used to explore the mechanism of Neu5Gc endocytosis and exocytosis by Caco-2 cells. Amiloride hydrochloride and cytochalasin D had the strongest inhibitory effect on the endocytosis of Neu5Gc. Sodium azide, dynasore, chlorpromazine hydrochloride, and nystatin also inhibited Neu5Gc endocytosis. Dynasore exhibited a stronger inhibitory effe...

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com