Protective humoral immunity in guinea pigs induced by PCV2 virus-like particles displaying the B cell linear epitope ((228)QQITDA(233)) of PPV1.

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成果类型：

期刊论文

作者：

Wang, Naidong;Zhang, Sujiao;Wang, Dongliang;Li, Fuqiang;Liang, Lin;...

通讯作者：

Tu, Di;Cui, Shangjin

作者机构：

[Wang, Dongliang; Yu, Wanting; Tu, Di; Zou, Yawen; Wang, Naidong; Zhan, Yang; Chen, Guanyu; Zhang, Sujiao; Deng, Zhibang] Hunan Agr Univ, Coll Vet Med, Res Ctr Reverse Vaccinol, Hunan Prov Key Lab Prot Engn Anim Vaccines,Lab Fu, Changsha 410128, Hunan, Peoples R China.

[Cui, Shangjin; Liang, Lin] Chinese Acad Agr Sci, IAS, Beijing 100193, Peoples R China.

[Li, Fuqiang; Li, Xiuli] Tianjin Anim Husb & Vet Res Inst, Tianjin 300381, Peoples R China.

[Cui, Shangjin; Liang, Lin] Minist Agr, Scientifc Observat & Expt Stn Vet Drugs & Diagnos, Beijing 100193, Peoples R China.

通讯机构：

[Tu, Di] H

[Cui, Shangjin] C

Hunan Agr Univ, Coll Vet Med, Res Ctr Reverse Vaccinol, Hunan Prov Key Lab Prot Engn Anim Vaccines,Lab Fu, Changsha 410128, Hunan, Peoples R China.

Chinese Acad Agr Sci, IAS, Beijing 100193, Peoples R China.

语种：

英文

关键词：

Guinea pig;Porcine circovirus type 2;Porcine parvovirus;Subunit vaccine;Virus-like particles

期刊：

Veterinary Microbiology

ISSN：

0378-1135

年：

2019

卷：

235

页码：

86-92

DOI：

10.1016/j.vetmic.2019.06.002

基金类别：

National Key Research and Development Program of China [2016YFD0501003, 2017YFD0502300, 2017YFD0501603]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31873019]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2018JJ2177]; Agricultural Science and Technology Innovation Program of China [ASTIP-IAS15]

机构署名：

本校为第一且通讯机构

院系归属：

动物医学院

摘要：

Although PCV2 infections generally cause mild disease in pigs, concurrent co-infections with other pathogens can damage the immune system and cause more severe diseases, collectively termed porcine circovirus associated diseases (PCVAD). Involvement of porcine parvovirus (PPV, a common cause of reproductive failure in naïve dams) in PCVAD caused by PCV2, has been reported. As this co-infection can be difficult to eliminate, there is a critical need to develop an effective vaccine to protect against PPV or synergistic effects of PCV2 and PPV un...

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Protective humoral immunity in guinea pigs induced by PCV2 virus-like particles displaying the B cell linear epitope ((228)QQITDA(233)) of PPV1.

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