Truncated Rep protein of porcine circovirus 2 (PCV2) caused by a naturally occurring mutation reduced virus replication in PK15 cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Hu, Yi;Cai, Xiong;Zhan, Yang;Yuan, Xiaomin;Liu, Tanbin;...

通讯作者：

Wang, Aibing;Guo, Shiyin

作者机构：

[Yang, Lingchen; Liu, Wei; Wang, Aibing; Tan, Lei; Li, Yalan; Yuan, Xiaomin; Hu, Yi; Liu, Tanbin] Hunan Agr Univ HUNAU, Coll Vet Med, Key Lab Anim Vaccine & Prot Engn, LAMFG, Changsha 410128, Hunan, Peoples R China.

[Cai, Xiong] Hunan Univ Chinese Med, Inst Innovat & Appl Res Chinese Med, Changsha 410208, Hunan, Peoples R China.

[Zhan, Yang; Wang, Naidong; Deng, Zhibang; Yang, Yi] HUNAU, Coll Vet Med, Key Lab Anim Vaccine & Prot Engn, LFP, Changsha 410128, Hunan, Peoples R China.

[Zhang, Lijie] Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China.

[Zhang, Lijie] Nankai Univ, Coll Pharm, Tianjin 300071, Peoples R China.

通讯机构：

[Wang, Aibing; Guo, Shiyin] H

Hunan Agr Univ HUNAU, Coll Vet Med, Key Lab Anim Vaccine & Prot Engn, LAMFG, Changsha 410128, Hunan, Peoples R China.

HUNAU, Coll Food Sci & Technol, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

Porcine circovirus 2(PCV2);Truncated Rep protein;Infectious clone;Rescued viruses;Virus replication;PCV2 evolution

期刊：

BMC Veterinary Research

ISSN：

1746-6148

年：

2019

卷：

期：

页码：

1-10

DOI：

10.1186/s12917-019-1984-8

基金类别：

This work was supported by: General Program of National Natural Science Foundation of China (Grants No. 31571432); Hunan Provincial Natural Science Foundation of China (Grant No. 2015JC3097). Support was also provided by “Shennong” Scholar funding to Aibing Wang.

机构署名：

本校为通讯机构

院系归属：

动物医学院

食品科学技术学院

摘要：

Background: Porcine circovirus 2 (PCV2) is the causative agent of porcine circovirus-associated diseases (PCVADs). The infection of PCV2 is widespread and has serious consequence, thereby causing significant economic losses in the swine industry worldwide. Previously, we found that a strain named YiY-3-2-3 has a naturally occurring point mutation (G710 to A710) in ORF1 region, which leads to a shorten product of the rep gene (945 to 660 base pair). Importantly, the Rep protein is responsible for genome replication of PCV2. To explore the effect...

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Truncated Rep protein of porcine circovirus 2 (PCV2) caused by a naturally occurring mutation reduced virus replication in PK15 cells

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