Truncated Rep protein of porcine circovirus 2 (PCV2) caused by a naturally occurring mutation reduced virus replication in PK15 cells

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成果类型：

期刊论文

作者：

Hu, Yi;Cai, Xiong;Zhan, Yang;Yuan, Xiaomin;Liu, Tanbin;...

通讯作者：

Wang, AB;Guo, SY

作者机构：

[Yang, Lingchen; Liu, Wei; Wang, Aibing; Tan, Lei; Li, Yalan; Yuan, Xiaomin; Hu, Yi; Liu, Tanbin; Wang, AB] Hunan Agr Univ HUNAU, Coll Vet Med, Key Lab Anim Vaccine & Prot Engn, LAMFG, Changsha 410128, Hunan, Peoples R China.

[Cai, Xiong] Hunan Univ Chinese Med, Inst Innovat & Appl Res Chinese Med, Changsha 410208, Hunan, Peoples R China.

[Zhan, Yang; Wang, Naidong; Deng, Zhibang; Yang, Yi] HUNAU, Coll Vet Med, Key Lab Anim Vaccine & Prot Engn, LFP, Changsha 410128, Hunan, Peoples R China.

[Zhang, Lijie] Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China.

[Zhang, Lijie] Nankai Univ, Coll Pharm, Tianjin 300071, Peoples R China.

通讯机构：

[Wang, AB ; Guo, SY ] H

Hunan Agr Univ HUNAU, Coll Vet Med, Key Lab Anim Vaccine & Prot Engn, LAMFG, Changsha 410128, Hunan, Peoples R China.

HUNAU, Coll Food Sci & Technol, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

Porcine circovirus 2(PCV2);Truncated Rep protein;Infectious clone;Rescued viruses;Virus replication;PCV2 evolution

期刊：

BMC Veterinary Research

ISSN：

1746-6148

年：

2019

卷：

期：

页码：

1-10

DOI：

10.1186/s12917-019-1984-8

基金类别：

This work was supported by: General Program of National Natural Science Foundation of China (Grants No. 31571432); Hunan Provincial Natural Science Foundation of China (Grant No. 2015JC3097). Support was also provided by “Shennong” Scholar funding to Aibing Wang.

机构署名：

本校为通讯机构

院系归属：

动物医学院

食品科学技术学院

摘要：

Porcine circovirus 2 (PCV2) is the causative agent of porcine circovirus-associated diseases (PCVADs). The infection of PCV2 is widespread and has serious consequence, thereby causing significant economic losses in the swine industry worldwide. Previously, we found that a strain named YiY-3-2-3 has a naturally occurring point mutation (G710 to A710) in ORF1 region, which leads to a shorten product of the rep gene (945 to 660 base pair). Importantly, the Rep protein is responsible for genome replication of PCV2. To explore the effects of this mutation on the PCV2 replication, in the current stu...

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Truncated Rep protein of porcine circovirus 2 (PCV2) caused by a naturally occurring mutation reduced virus replication in PK15 cells

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