Diminished caudate and superior temporal gyrus responses to effort-based decision making in patients with first-episode major depressive disorder

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成果类型：

期刊论文

作者：

Yang, Xin-hua;Huang, Jia;Lan, Yong;Zhu, Cui-ying;Liu, Xiao-qun;...

通讯作者：

Xie, Guang-rong

作者机构：

[Yang, Xin-hua; Xie, Guang-rong; Wang, Ye-fei] Cent S Univ, Natl Technol Inst Psychiat, Key Lab Psychiat & Mental Hlth Hunan Prov, Mental Hlth Inst,Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China.

[Yang, Xin-hua; Lan, Yong; Zhu, Cui-ying] Hunan Agr Univ, Coll Business, Changsha, Hunan, Peoples R China.

[Chan, Raymond C. K.; Huang, Jia] Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China.

[Liu, Xiao-qun] Cent S Univ, Sch Publ Hlth, Changsha, Hunan, Peoples R China.

[Cheung, Eric F. C.] Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China.

通讯机构：

[Xie, Guang-rong] C

Cent S Univ, Mental Hlth Inst, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China.

语种：

英文

关键词：

Anhedonia;Depression;Effort-based decision-making;Motivation;Reward processing

期刊：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

ISSN：

0278-5846

年：

2016

卷：

期：

页码：

52-59

DOI：

10.1016/j.pnpbp.2015.07.006

基金类别：

National Science Fund China [81371492, 81088001, 31100747]; Chinese Society of Academic Degrees and Graduate Education [2013Y13]; 'Strategic Priority Research Program (B)' of the Chinese Academy of Sciences [XDB02030002]; Beijing Training Project for the Leading Talents in S T [Z151100000315020]; Key Laboratory of Mental Health, Institute of Psychology; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2015M571149]

机构署名：

本校为其他机构

院系归属：

商学院

摘要：

Background: Anhedonia, the loss of interest or pleasure in reward processing, is a hallmark feature of major depressive disorder (MDD), but its underlying neurobiological mechanism is largely unknown. The present study aimed to examine the underlying neural mechanism of reward-related decision-making in patients with MDD. Method: We examined behavioral and neural responses to rewards in patients with first-episode MDD (N=25) and healthy controls (N=25) using the Effort-Expenditure for Rewards Task (EEfRT). The task involved choices about possible rewards of varying magnitude and probability. W...

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Diminished caudate and superior temporal gyrus responses to effort-based decision making in patients with first-episode major depressive disorder

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