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Diminished caudate and superior temporal gyrus responses to effort-based decision making in patients with first-episode major depressive disorder

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成果类型:
期刊论文
作者:
Yang, Xin-hua;Huang, Jia;Lan, Yong;Zhu, Cui-ying;Liu, Xiao-qun;Wang, Ye-fei;Cheung, Eric F. C.;Xie, Guang-rong*;Chan, Raymond C. K.
通讯作者:
Xie, Guang-rong
作者机构:
[Yang, Xin-hua; Xie, Guang-rong; Wang, Ye-fei] Cent S Univ, Natl Technol Inst Psychiat, Key Lab Psychiat & Mental Hlth Hunan Prov, Mental Hlth Inst,Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China.
[Yang, Xin-hua; Lan, Yong; Zhu, Cui-ying] Hunan Agr Univ, Coll Business, Changsha, Hunan, Peoples R China.
[Chan, Raymond C. K.; Huang, Jia] Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China.
[Liu, Xiao-qun] Cent S Univ, Sch Publ Hlth, Changsha, Hunan, Peoples R China.
[Cheung, Eric F. C.] Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China.
通讯机构:
[Xie, Guang-rong] Cent S Univ, Mental Hlth Inst, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China.
语种:
英文
关键词:
Anhedonia;Depression;Effort-based decision-making;Motivation;Reward processing
期刊:
Progress in Neuro-Psychopharmacology and Biological Psychiatry
ISSN:
0278-5846
年:
2016
卷:
64
页码:
52-59
基金类别:
National Science Fund China [81371492, 81088001, 31100747]; Chinese Society of Academic Degrees and Graduate Education [2013Y13]; 'Strategic Priority Research Program (B)' of the Chinese Academy of Sciences [XDB02030002]; Beijing Training Project for the Leading Talents in S T [Z151100000315020]; Key Laboratory of Mental Health, Institute of Psychology; China Postdoctoral Science Foundation [2015M571149]
机构署名:
本校为其他机构
院系归属:
商学院
摘要:
Background: Anhedonia, the loss of interest or pleasure in reward processing, is a hallmark feature of major depressive disorder (MDD), but its underlying neurobiological mechanism is largely unknown. The present study aimed to examine the underlying neural mechanism of reward-related decision-making in patients with MDD. Method: We examined behavioral and neural responses to rewards in patients with first-episode MDD (N=25) and healthy controls (N=25) using the Effort-Expenditure for Rewards Task (EEfRT). The task involved choices about possible rewards of varying magnitude and probability. We tested the hypothesis that individuals with MDD would exhibit a reduced neural response in reward-related brain structures involved in cost-benefit decision-making. Results: Compared with healthy controls, patients with MDD showed significantly weaker responses in the left caudate nucleus when contrasting the 'high reward'-'low reward' condition, and blunted responses in the left superior temporal gyrus and the right caudate nucleus when contrasting high and low probabilities. In addition, hard tasks chosen during high probability trials were negatively correlated with superior temporal gyrus activity in MDD patients, while the same choices were negatively correlated with caudate nucleus activity in healthy controls. Conclusions: These results indicate that reduced caudate nucleus and superior temporal gyrus activation may underpin abnormal cost-benefit decision-making in MDD. (C) 2015 Elsevier Inc. All rights reserved.

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