期刊论文

中文

时珍国医国药

1008-0805

2009

20

3

679-680

10.3969/j.issn.1008-0805.2009.03.086

本校为其他机构

目的 研究杜仲提取物的致突变性,为其应用提供理论依据.方法 对实验小鼠灌服不同剂量的杜仲提取物水溶液,检测小鼠骨髓微核率、精子畸形率及采用鼠伤寒沙门氏菌回复突变实验(Ames实验)进行观察.结果 杜仲提取物水溶液对小鼠骨髓嗜多染红细胞微核率无影响;对小鼠精子无畸形诱变作用;对供试菌株无致突变作用.结论 杜仲提取物对受试物未见有明显的致突变作用.

Objective To study the mutagenicity of Eucommia ulmoides extract solution, in order to provide basis for clinic use. Methods The experiment mice were given different doses of Eucommia ulmoides extract solution, the mieronucleus test of bone marrow cells（ PCE）, sperm deformity and reversion assay were tested. Results Eucommia ulmoides extract solution had no effect on mouse PCE, no deformed change of mouse sperms and no mutagenicity of Ames test....