In this paper, we present a solution-region-based synthesis approach for selecting optimal four-bar linkages with a Ball–Burmester point. We discuss both general and special cases of the Burmester point that coincide with the Ball point at the pole of the inflection circle. Given the coordinates of one fixed joint, any point on the target's straight line, and the direction of this straight line, we can synthesize an infinite number of mechanisms using a coupler curve with five-point contacts with its tangent by adopting the proposed approach. ...