A 8-week feeding trial was conducted to study the effect of dietary guanidinoacetic acid (GAA) on the growth performance, hepatic anti-oxidative capacity and muscle energy metabolism of channel catfish (Ictalurus punctatus). Four isonitrogenous and isocaloric experimental diets with 0 (control diet), 300, 600, and 900 mg/kg GAA (GAA0, GAA300, GAA600, and GAA900) were formulated. The results showed that appropriate dietary GAA could improve the average final body weight (FBW) and weight gain rate (WGR), but not significantly. While the visceroso...