Inhibition of the NF-κB pathway and ERK-mediated mitochondrial apoptotic pathway takes part in the mitigative effect of betulinic acid on inflammation and oxidative stress in cyclophosphamide-triggered renal damage of mice

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成果类型：

期刊论文

作者：

Zhu, Lijuan;Luo, Chenxi;Ma, Chaoyang;Kong, Li;Huang, You;...

通讯作者：

Jiang, Weiwei;Yi, Jine

作者机构：

[Luo, Chenxi; Huang, You; Zhu, Lijuan; Huang, Chunlin; Yi, Jine; Ma, Chaoyang; Kong, Li; Yang, Wenjiang] Hunan Agr Univ, Coll Vet Med, Hunan Engn Res Ctr Livestock & Poultry Hlth Care, Changsha 410128, Peoples R China.

[Jiang, Weiwei] Hunan Polytech Environm & Biol, Coll Med Technol, Hengyang 421005, Peoples R China.

通讯机构：

[Yi, Jine] H

[Jiang, Weiwei] C

College of Medical Technology, Hunan Polytechnic of Environment and Biology, Hengyang 421005, China. Electronic address:

Hunan Engineering Research Center of Livestock and Poultry Health Care, College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China. Electronic address:

语种：

英文

关键词：

Betulinic acid;Cyclophosphamide;Mitochondrial apoptotic pathway;NF-κB/ERK signaling pathways;Renal damage

期刊：

Ecotoxicology and Environmental Safety

ISSN：

0147-6513

年：

2022

卷：

246

页码：

114150

DOI：

10.1016/j.ecoenv.2022.114150

基金类别：

This study was supported by the National Natural Science Foundation of China (Grant no. 32273084 ), the Natural Science Foundation of Hunan Province , China (Grant no. 2020JJ4368 ), the Special Funds for Construction of Innovative Provinces in Hunan Province , China (Grant no. 2020NK2032 ), Innovation Foundation for Postgraduate of Hunan Province , China (Grant no. CX20220670 ), and Innovation Foundation for Postgraduate of Hunan Agricultural University , China (Grant no. 2022XC010 ).

机构署名：

本校为第一机构

院系归属：

动物医学院

摘要：

Betulinic acid (BA), an occurring pentacyclic triterpenoid, has various biological activities, such as anti-inflammation and antioxidation. Previous studies found that BA attenuated cyclophosphamide (CYP)-induced intestinal mucosal damage by inhibiting intestinal mucosal barrier dysfunctions and cell apoptosis. However, the effects and regulation mechanisms of BA on CYP-induced renal damage has not been reported in literature. Here, we found that BA pretreatment alleviated the elevation of serum urea level and inhibited the increase in serum ne...

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Inhibition of the NF-κB pathway and ERK-mediated mitochondrial apoptotic pathway takes part in the mitigative effect of betulinic acid on inflammation and oxidative stress in cyclophosphamide-triggered renal damage of mice

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