Exploration of the Polymorphism Distribution of Bovine HMGA2 Gene in Worldwide Breeds and Its Associations with Ovarian Traits

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成果类型：

期刊论文

作者：

Shen, Siyuan;Zhu, Leijing;Yang, Yuanzhe;Bi, Yi;Li, Jie;...

通讯作者：

Shuilian Wang<&wdkj&>Xianyong Lan

作者机构：

[Wang, Yongsheng] College of Veterinary Medicine, Northwest A&F University, Yangling 712100, China

These authors contributed equally to this work.

[Pan, Chuanying; Bi, Yi; Yang, Yuanzhe; Li, Jie] College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China

Authors to whom correspondence should be addressed.

College of Veterinary Medicine, Hunan Agricultural University, Changsha 410125, China

通讯机构：

[Shuilian Wang; Xianyong Lan] A

Authors to whom correspondence should be addressed.<&wdkj&>College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China<&wdkj&>Authors to whom correspondence should be addressed.<&wdkj&>College of Veterinary Medicine, Hunan Agricultural University, Changsha 410125, China

语种：

英文

关键词：

HMGA2;bovine;fertility;insertion–deletion (indel);ovarian traits

期刊：

ANIMALS

ISSN：

2076-2615

年：

2024

卷：

期：

页码：

796-

DOI：

10.3390/ani14050796

基金类别：

This work was supported by the National Key R&D Program of China (2022YFF1000100), the Shaanxi Provincial Innovation Leadership Program in Sciences and Technologies for Young and Middle-aged Scientists (No.2023SR205), the Agricultural Improved Seed Project of Shandong Province under Grant No. 2020LZGC014, and the Project of Undergraduate Science and Technology Innovation Items of Northwest A&F University (X202310712707).

机构署名：

本校为通讯机构

院系归属：

动物医学院

摘要：

The high-mobility group AT-hook 2(HMGA2) gene has been widely studied in the context of cancer and animal growth. However, recently, several studies have uncovered its critical role in cell proliferation. A genome-wide association study (GWAS) further suggests that the HMGA2 gene is a candidate gene in fertility, indicating its connection not only to growth traits but also to reproduction, specifically ovarian traits. Thus, this study aimed to analyze the distribution of the HMGA2 gene in 54 bovine breeds worldwide, identify important short fragment variants (indels), and investigate the relat...

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Exploration of the Polymorphism Distribution of Bovine HMGA2 Gene in Worldwide Breeds and Its Associations with Ovarian Traits

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