Theaflavin Promotes Myogenic Differentiation by Regulating the Cell Cycle and Surface Mechanical Properties of C2C12 Cells

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成果类型：

期刊论文

作者：

Qu, Zhihao;Liu, Changwei;Li, Penghui;Xiong, Wei;Zeng, Zhaoyang;...

通讯作者：

Liu, Zhonghua;Zhang, Sheng

作者机构：

[Liu, Changwei; Liu, Zhonghua; Xiao, Wenjun; Zhang, Sheng; Huang, Jianan; Qu, Zhihao] Hunan Agr Univ, Key Lab Tea Sci, Minist Educ, Changsha 410128, Hunan, Peoples R China.

[Liu, Changwei; Liu, Zhonghua; Xiao, Wenjun; Zhang, Sheng; Huang, Jianan; Qu, Zhihao] Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Funct Ingredie, Collaborat Innovat Ctr Utilizat Funct Ingredients, Changsha 410128, Hunan, Peoples R China.

[Li, Penghui] Fudan Univ, Sch Life Sci, Shanghai 200433, Peoples R China.

[Zeng, Zhaoyang; Xiong, Wei] Cent South Univ, Canc Res Inst, Key Lab Carcinogenesis & Canc Invas, Chinese Minist Educ, Changsha 410008, Hunan, Peoples R China.

[Liu, Ailing] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Liu, ZH; Zhang, S] H

Hunan Agr Univ, Key Lab Tea Sci, Minist Educ, Changsha 410128, Hunan, Peoples R China.

Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Funct Ingredie, Collaborat Innovat Ctr Utilizat Funct Ingredients, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

theaflavins;aging;skeletal muscle;myogenic differentiation

期刊：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN：

0021-8561

年：

2020

卷：

期：

页码：

9978-9992

DOI：

10.1021/acs.jafc.0c03744

基金类别：

National Key RD Project [2017YFD0400803]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2019JJ40120]; Key R&D Project of Hunan Province [2020NK2081]; Changsha Science and Technology Major Project [kq1703003]; Graduate Innovative Research Project of Hunan Province [CX2018B421]

机构署名：

本校为第一且通讯机构

院系归属：

园艺园林学院

生物科学技术学院

摘要：

Aging and muscle diseases often lead to a decline in the differentiation capacity of myoblasts, which in turn results in the deterioration of skeletal muscle (SkM) function and impairment of regeneration ability after injury. Theaflavins, the "gold molecules"found in black tea, have been reported to possess various biological activities and have a positive effect on maintaining human health. In this study, we found that among the four theaflavins (theaflavin (TF1), theaflavin-3-gallate (TF2A), theaflavin-3-gallate (TF2B), and theaflavin-3,3-dig...

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Theaflavin Promotes Myogenic Differentiation by Regulating the Cell Cycle and Surface Mechanical Properties of C2C12 Cells

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