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Molecular Mechanism of Vine Tea Dihydromyricetin Extract on Alleviating Glucolipid Metabolism Disorder in db/db Mice: Based on Liver RNA-Seq and TLR4/MyD88/NF-κB Pathway.

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成果类型:
期刊论文
作者:
Zhou, Xixin;Liu, Xin;Yi, Yuhang;Chen, Shiyun;Zhang, Yi;...
作者机构:
[Yi, Yuhang; Lv, Chenghao; Zhang, Yi; Liu, Xin; Zhou, Xixin] College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China
[Chen, Shiyun; Qin, Si; Fan, Wei] College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China
[Lv, Chenghao] Xiangya School of Basic Medical Sciences, Central South University, Changsha 410013, China
语种:
英文
关键词:
RNA-seq;TLR4/MyD88/NF-?B pathway;dihydromyricetin;glucolipid metabolic disorder;vine tea
期刊:
International Journal of Molecular Sciences
年:
2025
卷:
26
期:
5
机构署名:
本校为第一机构
院系归属:
食品科学技术学院
生物科学技术学院
摘要:
The primary active compound in vine tea is dihydromyricetin (DMY), which has a longstanding history as a dietary supplement and traditional ethnic medicine. However, the precise molecular mechanism by which vine tea dihydromyricetin extract (VDMY) regulates glucolipid metabolic disorder remains unclear. In this study, we first assessed the effect of VDMY on various physiological parameters in db/db mice, followed by RNA sequencing (RNA-seq) to identify key signaling pathways affected by VDMY in liver tissues. We also examined the impact of VDMY...

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