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Molecular Mechanism of Vine Tea Dihydromyricetin Extract on Alleviating Glucolipid Metabolism Disorder in db/db Mice: Based on Liver RNA-Seq and TLR4/MyD88/NF-κB Pathway

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成果类型:
期刊论文
作者:
Zhou, Xixin;Liu, Xin;Yi, Yuhang;Chen, Shiyun;Zhang, Yi;...
通讯作者:
Lv, CH;Qin, S
作者机构:
[Yi, Yuhang; Lv, Chenghao; Zhang, Yi; Liu, Xin; Zhou, Xixin] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.
[Chen, Shiyun; Qin, Si; Fan, Wei; Qin, S] Hunan Agr Univ, Coll Food Sci & Technol, Changsha 410128, Peoples R China.
[Lv, Chenghao] Cent South Univ, Xiangya Sch Basic Med Sci, Changsha 410013, Peoples R China.
通讯机构:
[Lv, CH ; Qin, S ] H
Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.
Hunan Agr Univ, Coll Food Sci & Technol, Changsha 410128, Peoples R China.
Cent South Univ, Xiangya Sch Basic Med Sci, Changsha 410013, Peoples R China.
语种:
英文
关键词:
RNA-seq;TLR4/MyD88/NF-?B pathway;dihydromyricetin;glucolipid metabolic disorder;vine tea
期刊:
International Journal of Molecular Sciences
ISSN:
1661-6596
年:
2025
卷:
26
期:
5
基金类别:
National Key Research and Development Program of China; Hunan Natural Science Foundation [2023JJ30295]; Changsha Natural Science Foundation [kq2208076]; [2019YFC1604903]
机构署名:
本校为第一且通讯机构
院系归属:
食品科学技术学院
生物科学技术学院
摘要:
The primary active compound in vine tea is dihydromyricetin (DMY), which has a longstanding history as a dietary supplement and traditional ethnic medicine. However, the precise molecular mechanism by which vine tea dihydromyricetin extract (VDMY) regulates glucolipid metabolic disorder remains unclear. In this study, we first assessed the effect of VDMY on various physiological parameters in db/db mice, followed by RNA sequencing (RNA-seq) to identify key signaling pathways affected by VDMY in liver tissues. We also examined the impact of VDMY...

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