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Betulinic acid protects against ovarian impairment by decreasing F-2 toxin-induced oxidative stress and inflammation associated with the downregulation of p38 expression in mice

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成果类型:
期刊论文
作者:
Li Kong;Xinyu Gao;Lijuan Zhu;Xing Lin;You Huang;...
通讯作者:
Zhihang Yuan<&wdkj&>Jin’e Yi
作者机构:
[Li Kong; Xinyu Gao; Lijuan Zhu; Xing Lin; You Huang; Chunlin Huang; Wenjiang Yang; Yazhi Chen; Haoqiang Zhao; Jing Wu; Zhihang Yuan; Jin’e Yi] Hunan Engineering Research Center of Livestock and Poultry Health Care, College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China
通讯机构:
[Zhihang Yuan; Jin’e Yi] H
Hunan Engineering Research Center of Livestock and Poultry Health Care, College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China
语种:
英文
关键词:
Betulinic acid;F-2 toxin;Ovarian damage;p38 MAPK signaling pathway
期刊:
食品科学与人类健康
ISSN:
2097-0765
年:
2024
卷:
13
期:
3
页码:
1292-1302
基金类别:
supported by the National Natural Science Foundation of China (32273084) the Special Funds for Construction of Innovative Provinces in Hunan Province,China (2020NK2032) the Natural Science Foundation of Hunan Province,China (2020JJ4368) Innovation Foundation for Postgraduate of Hunan Province,China (CX20220670) Innovation Foundation for Postgraduate of Hunan Agricultural University,China (2022XC010)。
机构署名:
本校为第一且通讯机构
院系归属:
动物医学院
摘要:
F-2 toxin is an estrogenic mycotoxin that causes reproductive disorders in animals. Betulinic acid (BA) is a natural pentacyclic lupane-structure triterpenoid that has diverse pharmacological activities. In this study, the antioxidative and anti-inflammatory effects of BA and its underlying mechanism are explored in F-2 toxin-triggered mouse ovarian damage. We found that BA alleviated the F-2 toxin-induced ovarian impairment by stimulating follicle growth, reducing inflammatory cell infiltration, repairing damaged mitochondria and endoplasmic r...
摘要(中文):
F-2 toxin is an estrogenic mycotoxin that causes reproductive disorders in animals.Betulinic acid(BA)is a natu...展开更多 F-2 toxin is an estrogenic mycotoxin that causes reproductive disorders in animals.Betulinic acid(BA)is a natural pentacyclic lupane-structure triterpenoid that has diverse pharmacological activities.In this study,the antioxidative and anti-inflammatory effects of BA and its underlying mechanism are explored in F-2 toxin-triggered mouse ovarian damage.We found that BA alleviated the F-2 toxin-induced ovarian impairment by st...

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