VEGF-A regulates sFlt-1 production in trophoblasts through both Flt-1 and KDR receptors

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成果类型：

期刊论文

作者：

Xiao, Zhonglin;Li, Songjun;Yu, Yan;Li, Mengxia;Chen, Jie;...

通讯作者：

Fan, Xiujun;Yang, Qing;Deng, Weifen

作者机构：

[Xiao, Zhonglin; Zhang, Jian; Li, Mengxia; Chen, Jie; Fan, Xiujun] Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China.

[Xiao, Zhonglin; Yang, Qing] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

[Deng, Weifen; Li, Songjun; Wang, Feng] Shenzhen Armed Police Hosp, Reprod Ctr, Shenzhen 518023, Peoples R China.

[Yu, Yan] Baoan Womens & Childrens Hosp, Shenzhen 518133, Peoples R China.

通讯机构：

[Fan, Xiujun] C

[Yang, Qing] H

[Deng, Weifen] S

Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China.

Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

Preeclampsia;Signaling pathways;sFlt-1;VEGF-A

期刊：

Molecular and Cellular Biochemistry

ISSN：

0300-8177

年：

2018

卷：

449

期：

1-2

页码：

1-8

DOI：

10.1007/s11010-018-3337-5

基金类别：

National Key Research and Development Program of China [2016YFC1000402]; National Natural Science FoundationNational Natural Science Foundation of China (NSFC) [81571445]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2016A030313178]; Shenzhen Basic Research Fund [JCYJ2015052109 4519488]

机构署名：

本校为通讯机构

院系归属：

动物医学院

摘要：

Studies have shown that sFlt-1 overproduction stimulated by excess VEGF of deciduous origin in trophoblasts can cause preeclampsia. However, the mechanism underlying how VEGF regulates sFtl-1 expression in trophoblasts remains unknown. To address this issue, JEG3 and HTR-8/SV neo (HTR8) trophoblast cell lines were used to investigate the signaling pathways involved in the regulation of sFlt-1 production via VEGF overexpression in vitro. JEG3 (VEGF-GFP-JEG3, V-J) and HTR8 (VEGF-GFP-HTR8, V-H) cells overexpressing VEGF165 were established by infecting the JEG3 and HTR8 cell lines with lentivirus...

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VEGF-A regulates sFlt-1 production in trophoblasts through both Flt-1 and KDR receptors

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