Abstract: This article analyzes the annul use of synthetic opioids at the state and county levels in Kentucky, Ohio, Pennsylvania, Virginia, and West Virginia during the year 2010-2017. After carrying out the visual analysis of the data, the general transfer trend of two target substances can be initially determined, and the results show that the use of target substances is more serious at cities on the border. Then, we select the use of heroin as the reference sequence and make oxycodone, fentanyl, hydrocodeine and buprenorphine represent the ...