版权说明 操作指南
首页 > 成果 > 详情

Selection and Identification of an ssDNA Aptamer for Fibroblast Activation Protein

认领
导出
Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Zhang, Xiaomin;Yang, Ge;Zhao, Yi;Dai, Xuyan;Liu, Wenjing;...
通讯作者:
Yuanyu Huang<&wdkj&>Ge Yang
作者机构:
[Qu, Feng; Huang, Yuanyu; Zhao, Yi; Yang, Ge; Zhang, Xiaomin] Beijing Inst Technol, Adv Res Inst Multidisciplinary Sci, Sch Life Sci, Key Lab Mol Med & Biotherapy,Key Lab Med Mol Sci &, Beijing 100081, Peoples R China.
[Yang, Ge] Chinese Acad Med Sci & Peking Union Med Coll, CAMS Key Lab Antiviral Drug Res, Beijing Key Lab Antimicrobial Agents, Inst Med Biotechnol,NHC Key Lab Biotechnol Antibio, Beijing 100050, Peoples R China.
[Dai, Xuyan] Hunan Agr Univ, Econ Coll, Changsha 410128, Peoples R China.
[Liu, Wenjing] Capital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Res Inst, Beijing Key Lab Drug Resistance TB Res, Beijing 101125, Peoples R China.
通讯机构:
[Yuanyu Huang; Ge Yang] A
Authors to whom correspondence should be addressed.<&wdkj&>Key Laboratory of Molecular Medicine and Biotherapy, Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, School of Life Science, Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology, Beijing 100081, China<&wdkj&>Authors to whom correspondence should be addressed.<&wdkj&>Key Laboratory of Molecular Medicine and Biotherapy, Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, School of Life Science, Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology, Beijing 100081, China<&wdkj&>CAMS Key Laboratory of Antiviral Drug Research, Beijing Key Laboratory of Antimicrobial Agents, NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
语种:
英文
关键词:
FAP;aptamer;CE;SELEX;cancer-associated fibroblasts
期刊:
Molecules
ISSN:
1420-3049
年:
2023
卷:
28
期:
4
页码:
1682-
基金类别:
This research was funded by the National Natural Science Foundation of China (21874010, 32101148), the Beijing Nova Program from Beijing Municipal Science & Technology Commission (Z201100006820005), Beijing Municipal Natural Science Foundation (7222310), and the Fundamental Research Funds for the Central Universities (3332022055).
机构署名:
本校为其他机构
院系归属:
经济学院
摘要:
As a type II transmembrane serine protease, fibroblast activation protein (FAP) is specifically expressed on the surface of fibroblasts associated with a variety of epithelial-derived malignancies such as pancreatic cancer, breast cancer, and colon cancer. It participates in the processes of tumorigenesis, progression, and immunosuppression. FAP constitutes an important target for tumor treatment; however, the current studies on FAP are mainly related to structural characteristics, enzymatic properties, and biological functions, and aptamers of FAP have not been investigated. In this work, by ...

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com