hnRNP K regulates mitochondrial apoptosis induced by porcine circovirus type 3 capsid protein

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成果类型：

期刊论文

作者：

He, Qing;Cao, Siyu;Yu, Wanting;Li, Zhoumian;Liu, Weijiao;...

通讯作者：

Wang, ND

作者机构：

[Liu, Weijiao; He, Qing; Li, Dantong; Zou, Yawen; Yu, Beilei; Zhan, Yang; Wu, Jing; Wang, Naidong; Wang, ND; Cao, Siyu; Li, Zhoumian; Jiang, You; Yang, Yi] Hunan Agr Univ, Hunan Prov Key Lab Prot Engn Anim Vaccines, Lab Funct Prote LFP, Changsha, Peoples R China.

[Liu, Weijiao; He, Qing; Li, Dantong; Zou, Yawen; Yu, Beilei; Zhan, Yang; Wu, Jing; Wang, Naidong; Wang, ND; Cao, Siyu; Li, Zhoumian; Jiang, You; Yang, Yi] Hunan Agr Univ, Coll Vet Med, Res Ctr Reverse Vaccinol RCRV, Changsha, Peoples R China.

[Yu, Wanting] Jiangxi Agr Univ, Coll Anim Sci & Technol, Nanchang, Jiangxi, Peoples R China.

[Tian, Chuanwen] Chinese Acad Agr Sci, Shanghai Vet Res Inst, Biosafety Res Ctr, Key Lab Anim Biosafety Risk Prevent & Control Nort, Shanghai, Peoples R China.

通讯机构：

[Wang, ND ] H

Hunan Agr Univ, Hunan Prov Key Lab Prot Engn Anim Vaccines, Lab Funct Prote LFP, Changsha, Peoples R China.

Hunan Agr Univ, Coll Vet Med, Res Ctr Reverse Vaccinol RCRV, Changsha, Peoples R China.

语种：

英文

关键词：

Cap;HnRNP K;Mitochondrial apoptosis;Porcine circovirus type 3

期刊：

Veterinary Microbiology

ISSN：

0378-1135

年：

2025

卷：

306

页码：

110557

DOI：

10.1016/j.vetmic.2025.110557

基金类别：

CRediT authorship contribution statement Jiang You: Validation. Wu Jing: Validation, Data curation. He Qing: Writing – original draft, Methodology, Investigation, Data curation. Yang Yi: Supervision, acquisition. Cao Siyu: Investigation, Data curation. Wang Naidong: Writing – review & editing, Supervision, Methodology, acquisition. Yu Wanting: Validation, Formal analysis. Zhan Yang: Supervision, acquisition. Yu Beilei: Resources. Zou Yawen: Software, Project administration. Li Zhoumian: Validation, Formal

机构署名：

本校为第一且通讯机构

院系归属：

动物医学院

摘要：

Porcine circovirus type 3 (PCV3) is a globally emerging circovirus affecting pigs and other animals. The capsid protein (Cap) is the sole structural protein of PCV, with a crucial role in virus evolution and pathogenesis. Through interactions with host factors, Cap enables viral entry, transport, and replication while modifying various cellular processes. Cap protein-induced apoptosis has important implications for viral pathogenesis, but remains poorly defined. Herein, we demonstrated for the first time that PCV3 Cap induced cell cycle arrest of PK-15 cells in S-phase and initiated apoptosis ...

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hnRNP K regulates mitochondrial apoptosis induced by porcine circovirus type 3 capsid protein

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