Leucine Supplementation: A Novel Strategy for Modulating Lipid Metabolism and Energy Homeostasis

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成果类型：

期刊论文

作者：

Zhang, Lingyu;Li, Fengna*;Guo, Qiuping;Duan, Yehui;Wang, Wenlong;...

通讯作者：

Li, Fengna

作者机构：

[Zhang, Lingyu; Li, Fengna; Guo, Qiuping; Duan, Yehui; Wang, Wenlong; Yin, Yulong] Chinese Acad Sci, Inst Subtrop Agr, Hunan Prov Key Lab Anim Nutr Physiol & Metab Proc, Key Lab Agroecol Proc Subtrop Reg, Changsha 410125, Peoples R China.

[Zhang, Lingyu; Guo, Qiuping] Univ Chinese Acad Sci, Coll Adv Agr Sci, Beijing 100039, Peoples R China.

[Wang, Wenlong] Hunan Normal Univ, Sch Biol, Lab Anim Nutr & Human Hlth, Changsha 410018, Peoples R China.

[Zhong, Yinzhao] South China Agr Univ, Guangdong Prov Key Lab Anim Nutr Regulat, Guangzhou 510642, Peoples R China.

[Yang, Yuhuan] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Peoples R China.

通讯机构：

[Li, Fengna] C

Chinese Acad Sci, Inst Subtrop Agr, Hunan Prov Key Lab Anim Nutr Physiol & Metab Proc, Key Lab Agroecol Proc Subtrop Reg, Changsha 410125, Peoples R China.

语种：

英文

关键词：

adipokine;energy axis;leucine;lipid metabolism;microbiota

期刊：

Nutrients

ISSN：

2072-6643

年：

2020

卷：

期：

DOI：

10.3390/nu12051299

基金类别：

National Basic Research Program of ChinaNational Basic Research Program of China [2018YFD0500405]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31972582]; science and technology projects of Changsha [kq1801059]; STS regional key projects of the Chinese Academy of Science [KFJ-STS-QYZD-052]; Youth Innovation Team Project of ISA, CAS [2017QNCXTD_ZCS]; Earmarked Fund for China Agriculture Research System [CARS-35]

机构署名：

本校为其他机构

院系归属：

动物科学技术学院

摘要：

Lipid metabolism is an important and complex biochemical process involved in the storage of energy and maintenance of normal biological functions. Leucine, a branched amino acid, has anti-obesity effects on glucose tolerance, lipid metabolism, and insulin sensitivity. Leucine also modulates mitochondrial dysfunction, representing a new strategy to target aging, neurodegenerative disease, obesity, diabetes, and cardiovascular disease. Although various studies have been carried out, much uncertainty still exists and further studies are required t...

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Leucine Supplementation: A Novel Strategy for Modulating Lipid Metabolism and Energy Homeostasis

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