期刊论文

Study the Effect of Pleione yunnanensis Rolfe Polysaccharides on IL-2 and p53 Protein Expression

中文

食品研究与开发

1005-6521

2016

37

18

6-10

10.3969/j.issn.1005-6521.2016.18.002

中日政府间国际合作项目（2011DFA30490-2）；

本校为第一机构

研究山慈菇多糖对H22的体内抑制作用及其机制。建立小鼠H22腹水瘤和实体瘤模型观察山慈菇多糖的抑瘤作用，Elisa检测实体瘤小鼠外周血IL-2水平，HE染色法观察小鼠肿瘤组织的细胞形态，SABC免疫组化法检测p53蛋白表达情况。能改善腹水瘤小鼠的生存状态和延长生存天数，延长率为21.4%。实体瘤小鼠低、中、高剂量组抑瘤率分别为21.58%、32.76%、40.05%，IL-2的中高剂量组相对模型组都具有极显著性（P

To study on the anti-tumor effct and mechanism of Pleione yunnanensis Rolfe polysaccharides (PYRP) on mice with H22 hepatocellular carcinoma. The ascitic type and solid tumor of H22 were established to observe the anti-tumor effect of sinapine. Used Elisa To analyze the level of IL-2,TNFα from peripheral blood.HE staining was used to observe the cellular morphology. The thymus index and spleen index were used to analyze the influence of PYRP on the immune organs. Immunohistochemical (SABC) were used to study the apoptosis mechanism induced by ...