期刊论文

中文

食品研究与开发

1005-6521

2020

41

10

28-33,166

10.12161/j.issn.1005-6521.2020.10.005

海南省重大科技计划项目(ZDKJ2016003) 湖南省科技创新计划项目(2017SK2430)。

本校为第一机构

通过给予小鼠不同剂量鲜槟榔水提液(fresh areca nut water extract,FANE),记录每组小鼠体重增长、分析其血清细胞因子白介素-1(interleukin 1,IL-1)、α 肿瘤坏死因子(tumor necrosis factorα,TNF-α),免疫球蛋白A(immunoglobin A,IgA)、IgG与IgM水平,并通过高通量测序分析结肠微生物菌群的多样性与丰度变化,以探究槟榔灌胃小鼠免疫指标变化与小鼠肠道微生物菌群结构的关系.结果表明,低剂量FANE可显著提高小鼠IL-1的浓度,并降低其IgA和IgG的水平.高剂量FANE造成了小鼠TNF-α的显著降低以及IL-1浓度的显著增加,减少了血清IgA、IgG并提高了其IgM水平.这说明高剂量FANE可能造成了小鼠免疫功能的紊...

The purpose of this study was to explore the relationship between the changes of immune indexes and the structure of intestinal microflora in fresh areca nut water extract(FANE)gavage mice. Serum cytokine interleukin 1(IL-1),alpha tumor necrosis factor(TNF-α),immunoglobulin A(IgA),IgG and IgM level of each group of mice were analyzed and weight gain were calculated. Besides,the abundance of colonic microflora was analyzed by high throughput sequencing. The results showed that low-dose FANE significantly increased the concentration of IL-1 and ...