Betulinic acid mitigates zearalenone-induced liver injury by ERS/MAPK/Nrf2 signaling pathways in mice

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成果类型：

期刊论文

作者：

Wu, Jing;Li, Jiayan;Wu, You;Yang, Mengran;Chen, Yunqin;...

通讯作者：

Yi, Jine;Yang, CL

作者机构：

[Wu, Jing; Wang, Naidong; Chen, Yunqin; Wang, Ji; Li, Jiayan; Yi, Jine; Yang, Mengran; Yang, Chenglin; Wu, You; Yuan, Zhihang] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China.

[Wu, Jing; Chen, Yunqin; Wang, Ji; Li, Jiayan; Yang, Mengran; Yi, Jine; Yang, Chenglin; Wu, You; Yuan, Zhihang] Hunan Agr Univ, Hunan Engn Res Ctr Livestock & Poultry Hlth Care, Changsha 410128, Peoples R China.

[Wang, Naidong] Res Ctr Reverse Vaccinol, Hunan Prov Key Lab Prot Engn Anim Vaccines, Lab Funct Prote, Changsha 410128, Peoples R China.

通讯机构：

[Yi, JE; Yang, CL ] H

Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China.

语种：

英文

关键词：

Apoptosis;Betulinic acid;ERS/MAPK/Nrf2 pathway;Liver injury;Oxidative damage;Zearalenone

期刊：

Food and Chemical Toxicology

ISSN：

0278-6915

年：

2023

卷：

177

页码：

113811

DOI：

10.1016/j.fct.2023.113811

基金类别：

This work was supported by the Natural Science Foundation of Hunan province ( 2021JJ30343 and 2020JJ4368 ); The Special Funds for Construction of Innovative Provinces in Hunan Province ( 2020NK 2032 ); Innovation Research and Development Project of Hunan Development and Reform Commission (Grant No. 37 ).

机构署名：

本校为第一且通讯机构

院系归属：

动物医学院

摘要：

Zearalenone (ZEA) is a mycotoxin commonly found in cereals and feedstuffs, which can induce oxidative stress and inflammation to cause liver damage in humans and animals. Betulinic acid (BA) is extracted from pentacyclic triterpenoids of many natural plants and has anti-inflammatory, and anti-oxidation biological activities in many studies. However, the protective effect of BA on liver injury induced by ZEA has not been reported. Therefore, this study aims to explore the protective effect of BA on ZEA-induced liver injury and its possible mecha...

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Betulinic acid mitigates zearalenone-induced liver injury by ERS/MAPK/Nrf2 signaling pathways in mice

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