The field experiment was done to investigate the growth, quality and pathogenicity of flue-cured tobacco by applying different types of organic fertilizer combined with specialty fertilizer. The results indicated that, swine blood fermentation and rapeseed cake fertilizer could enhance the growth tendency, lengthen the growing period, increase the output. The effects of different fertilizers on pathogenicity, physical target and chemical composition was diverse. Rapeseed cake fertilizer is obviously better than swine blood fermentation and CK. ...