期刊论文

中文

湖南农业大学学报(自然科学版)

1007-1032

2010

36

3

330-334

10.3724/SP.J.1238.2010.00330

国家自然科学基金项目（30671548）；

本校为第一机构

采用25日龄健康的昆明种小鼠120只,分为空白对照组和圆弧青霉菌毒素-青霉酸（以下简称青霉酸）低、中、高剂量组进行试验,以探索青霉酸对小鼠肾脏的损伤及损伤机理.结果表明,青霉酸对小鼠肾脏的损伤作用主要是在肾小管上皮细胞;高剂量染毒能使小鼠肾小管上皮细胞空泡变性,细胞核出现固缩、溶解,相同剂量下雄性肾脏的损伤比雌性的严重;脂质过氧化反应是青霉酸引起肾损伤的作用机理,它能使小鼠肾组织中SOD活性降低及MDA含量上升,呈现剂量相关性;青霉酸通过促进Bax和P53基因的表达,抑制Bcl-2的表达,诱导肾小管上皮细胞发生凋亡.

120 Kunming mice（25 days old） were divided into 4 groups randomly,as control,low-dose group,middle-dose group and high-dose group,to find effects on kidney damage and its mechanism induced by a toxin of penicillic acid from Penicillium cyclopium.The results showed that renal tubular epithelial cells were severely damaged by penicillic acid.The epithelial cells showed vacuolar degeneration and nuclear condensation and dissolution.Under the same dose,the renal damage of male mouse was more serious than females.The main mechanism of kidney damag...