期刊论文

Screening cell division-related genes in Pasteurella multocida

中文

湖南农业大学学报(自然科学版)

1007-1032

2021

47

3

332-337

10.13331/j.cnki.jhau.2021.03.013

湖南省自然科学基金项目（2017JJ2116）；

本校为第一机构

为探讨多杀性巴氏杆菌(Pasteurella multocida,Pm)细胞分裂的分子机制,从GenBank下载不同宿主不同血清型Pm的全基因组,利用生物信息学在线分析方法筛选与Pm细胞分裂相关蛋白的编码基因,并鉴定含minC的操纵子.结果表明:发现33个与Pm细胞分裂相关蛋白的编码基因,其中14个为不同菌株的共有基因;未发现调节ftsZ聚合的Noc系统相关蛋白基因和min系统的minD和minE蛋白基因;发现1个由minC基因、脱氧核糖核酸酶基因(denⅤ)及1个未知功能的基因组成的操纵子;进一步分析发现,多个与denⅤ编码的脱氧核糖核酸酶denⅤ的相互作用蛋白具有与细胞分裂有关的结构域;Pm不同血清型菌株的生长曲线无明显差异.可见,Pm的...

To investigate the molecular mechanism on cell division of Pasteurella multocida(Pm), different serotypes genomes of Pm from different hosts were downloaded from GenBank database and were subjected to extensive analysis. First, genes encoding Pm cell division-associated proteins in different strains were screened and then the operon with minC was identified by bioinformatics methods. The results showed that a total of 33 genes encoding Pm cell division-related proteins were found, of them 14 genes were existed in all studied Pm strains. Genes e...