PLAC1 is involved in human trophoblast syncytialization

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chang, Wen-Lin;Wang, Huiying;Cui, Lina;Peng, Nan-Ni;Fan, Xiujun;...

通讯作者：

Xue, Li-Qun;Yang, Qing

作者机构：

[Chang, Wen-Lin; Xue, Li-Qun; Xue, LQ; Yang, Qing] Hunan Agr Univ, Coll Vet Med, 1 Nongda Rd, Changsha 410128, Hunan, Peoples R China.

[Chang, Wen-Lin; Cui, Lina] Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing, Peoples R China.

[Chang, Wen-Lin] Peking Univ, Shenzhen Hosp, Shenzhen PKUHKUST Med Ctr,Inst Urol, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Shenzhen, Peoples R China.

[Wang, Huiying] Capital Med Univ, Beijing Shijitan Hosp, Beijing, Peoples R China.

[Wang, Huiying] Capital Med Univ, Beijing Obstet & Gynecol Hosp, Beijing, Peoples R China.

通讯机构：

[Xue, LQ; Yang, Q] H

Hunan Agr Univ, Coll Vet Med, 1 Nongda Rd, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

*Cytotrophoblast;*PLAC1;*Syncytialization;*Syncytiotrophoblast

期刊：

Reproductive Biology

ISSN：

1642-431X

年：

2016

卷：

期：

页码：

218-224

DOI：

10.1016/j.repbio.2016.07.001

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31272630, 31172377]; Hunan Natural Science Fund for Distinguished Young Scholars Project [2015JJ1009]; Key Project of Chinese Ministry of EducationMinistry of Education, China [212121]

机构署名：

本校为第一且通讯机构

院系归属：

动物医学院

摘要：

Placenta specific protein 1 (PLAC1) is thought to be important for murine and human placentation because of its abundant expression in placenta; however, the trophoblast subtypes that express PLAC1 at the fetomaternal interface and the major role of PLAC1 in placentation are still unclear. This study investigated the expression pattern of PLAC1 at the human fetomaternal interface and its involvement in trophoblast syncytialization. Localization of PLAC1 at the fetomaternal interface was studied using in situ hybridization (ISH) and immunohistochemistry (IHC) assays. Real time RT-PCR and Wester...

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PLAC1 is involved in human trophoblast syncytialization

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