期刊论文

Transcatheter closure of atrial septal defect in patients over 60 years old

中文

南京医科大学学报（自然科学版）

Journal of Nanjing Medical University(Natural Sciences)

1007-4368

2016

36

5

593-596

10.7655/NYDXBNS20160516

国家自然科学基金(30901473)；

本校为其他机构

目的:研究米糠植物甾醇对非酒精性脂肪性肝炎(non-alcoholicsteatohepatitis,NASH)大鼠的干预治疗作用。方法:实验选用50只健康SD雄性大鼠,随机分为正常对照组、NASH模型组和米糠甾醇低、中、高3个剂量组(65、130、195mg/kg)。高脂饲料饲喂造模,各实验组同时进行米糠甾醇溶液灌胃干预。13周后观察各组大鼠肝组织病理学特点,测定血清中血脂总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇含量和谷丙转氨酶、谷草转氨酶、一氧化氮合酶和超氧化物歧化酶活性,并比较各组肝脏指数和脾脏指数。结果:肝脏组织切片观察到NASH模型组有明显的肝细胞脂肪变性和炎症聚集浸润,米糠甾醇各治疗组肝...

Objective：To evaluate the safety and effect of transcatheter closure of atrial septal defect（ASD）in patients aged over 60 years old. Methods：Fifty-one over 60-year-old patients underwent transcatheter ASD closure,and their clinic data and procedural outcome were analyzed in this study. Meanwhile,all the data and outcomes were compared with other age groups. Results：Patients above 60 years old with ASD（60ASD）accounted about 7.9%（51 / 647）of adult ASD patients. The incidence of atrial fibrillation in60ASD（27.45%）was significantly highe...