A wearable device for continuous immunoassay-based monitoring of C-peptide in interstitial fluid

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成果类型：

期刊论文

作者：

Chen, Shengbo;Guo, Ziyu;Lu, Boxi;Sun, Mengsi;Wang, Saijie;...

通讯作者：

Wang, Dou;Jiang, XY;Wang, D

作者机构：

[Wei, Qiwu; Lu, Boxi; Wang, Saijie; Chen, Shengbo; Jiang, Yizhou; Li, Shunhang; Jiang, Xingyu; Guo, Ziyu; Wang, Dou] Southern Univ Sci & Technol, Dept Biomed Engn, Guangdong Prov Key Lab Adv Biomat, Shenzhen Key Lab Smart Healthcare Engn, 1088 Xueyuan Rd, Shenzhen 518055, Guangdong, Peoples R China.

[Sun, Mengsi] Hunan Agr Univ, Coll Hort & Landscape, Changsha, Peoples R China.

[Wei, Qiwu] Chinese Acad Med Sci & Peking Union Med Coll, Natl Ctr Cardiovasc Dis, Fuwai Hosp, State Key Lab Cardiovasc Dis, Beijing 100037, Peoples R China.

[Wang, Dou] Guangzhou Med Univ, KingMed Sch Lab Med, Guangzhou 511436, Peoples R China.

通讯机构：

[Wang, D ] G

[Jiang, XY ; Wang, D] S

Southern Univ Sci & Technol, Dept Biomed Engn, Guangdong Prov Key Lab Adv Biomat, Shenzhen Key Lab Smart Healthcare Engn, 1088 Xueyuan Rd, Shenzhen 518055, Guangdong, Peoples R China.

Guangzhou Med Univ, KingMed Sch Lab Med, Guangzhou 511436, Peoples R China.

语种：

英文

期刊：

Science Advances

ISSN：

2375-2548

年：

2025

卷：

期：

页码：

eadw2182

DOI：

10.1126/sciadv.adw2182

基金类别：

Guangdong Innovative and Entrepreneurial Research Team Program : 2019ZT08Y191 the National Natural Science Foundation of China: 22427804, 22234004 the National Key R&D Program of China: 2020YFA0908900 the Shenzhen Science and Technology Program: KQTD20190929172743294, ZDSYS20200811144003009, JCYJ20220818101407017, SGDX20230116091642001 the Shenzhen Science and Technology Program: GJHZ20220913142610019 Tencent Foundation: XPLORER PRIZE Guangdong Provincial Key Laboratory of Advanced Biomaterials: 2022B1212010003 Guangdong Major Talent Introduction Project: 2019CX01Y196

机构署名：

本校为其他机构

院系归属：

园艺园林学院

摘要：

C-peptide is a critical biomarker for evaluating pancreatic β cell function and managing diabetes. However, conventional methods such as enzyme-linked immunosorbent assay are limited by lengthy processing times and the necessity for invasive sample collection. This study introduces a regenerable, portable, and wearable device for minimally invasive, real-time monitoring of C-peptide in dermal interstitial fluid (ISF). The device uses a microneedle array and negative pressure extraction for ISF collection. A double-antibody sandwich approach wa...

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A wearable device for continuous immunoassay-based monitoring of C-peptide in interstitial fluid

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