Preventive effect and mechanism of Tibetan tea extract on thrombosis in arachidonic acid-induced zebrafish determined via RNA-seq transcriptome profiles

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成果类型：

期刊论文

作者：

Wang, Ning;Lan, Chaohua;Lu, Huiqiang;Li, Linman;Liao, Dalong;...

通讯作者：

Zhu, H;Wu, T

作者机构：

[Liao, Dalong; Wang, Ning; Wei, Mengting; Lan, Chaohua; Zhu, Hui; Xu, Kewei; Li, Linman] Sichuan Univ Sci & Engn, Coll Bioengn, Zigong, Peoples R China.

[Wang, Ning] Luzhou Laojiao Co Ltd, Luzhou, Peoples R China.

[Wang, Ning] Hunan Agr Univ, Coll Hort, Changsha, Peoples R China.

[Wang, Ning; Sun, Haiyan; Tang, Yongqing] Chengdu Chongqing Shuangcheng Econ Circle Luzhou A, Luzhou, Peoples R China.

[Lu, Huiqiang] Gannan Normal Univ, Ctr Drug Screening & Res, Sch Geog & Environm Engn, Ganzhou, Peoples R China.

通讯机构：

[Wu, T ] X

[Zhu, H ] S

Sichuan Univ Sci & Engn, Coll Bioengn, Zigong, Peoples R China.

Xihua Univ, Sch Food & Biol Engn, Chengdu, Peoples R China.

语种：

英文

期刊：

PLOS ONE

ISSN：

1932-6203

年：

2023

卷：

期：

页码：

e0285216

DOI：

10.1371/journal.pone.0285216

基金类别：

Science and Technology Department of Sichuan Province [2020YFH0130]; Talent Introduction Project of Sichuan University of Science amp; Engineering [2019RC29]; Academician (Expert) Workstation Project of Sichuan University of Science amp;Engineering [2018YSCZZ01]; Innovation and Entrepreneurship Program for College Students [S202210622023]

机构署名：

本校为其他机构

院系归属：

园艺园林学院

摘要：

Thrombosis is a key pathological event in cardiovascular diseases and is also the most important targeting process for their clinical management. In this study, arachidonic acid (AA) was used to induce thrombus formation in zebrafish larvae. Blood flow, red blood cell (RBCs) aggregation and cellular oxidative stress were measured to evaluate the antithrombotic effect of Tibetan tea (TT). Meanwhile, the potential molecular mechanism was further explored by transcriptome sequencing (RNA-seq). The results indicated that TT could significantly restore heart RBCs intensity of thrombotic zebrafish, ...

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Preventive effect and mechanism of Tibetan tea extract on thrombosis in arachidonic acid-induced zebrafish determined via RNA-seq transcriptome profiles

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