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m6A mRNA Methylation Analysis Provides Novel Insights into Pigmentation in Sheep Skin

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成果类型:
期刊论文
作者:
Zhao, Yuanyuan;Meng, Jinzhu;Song, Xingchao;An, Qingming
通讯作者:
Meng, JZ
作者机构:
[Meng, Jinzhu; Song, Xingchao; An, Qingming; Zhao, Yuanyuan] Tongren Univ, Guizhou Prov Key Lab Biodivers Conservat & Utiliza, Tongren, Guizhou, Peoples R China.
[Meng, Jinzhu] Hunan Agr Univ, Coll Vet Med, Changsha, Hunan, Peoples R China.
[Meng, Jinzhu; Meng, JZ] Tongren Univ, Prov Key Lab Biodivers Conservat & Utilizat Fanjin, Tongren 554300, Guizhou, Peoples R China.
通讯机构:
[Meng, JZ ] T
Tongren Univ, Prov Key Lab Biodivers Conservat & Utilizat Fanjin, Tongren 554300, Guizhou, Peoples R China.
语种:
英文
关键词:
MeRIP-seq;Pigmentation;Sheep;m6A mRNA methylation
期刊:
Epigenetics
ISSN:
1559-2294
年:
2023
卷:
18
期:
1
页码:
2230662
基金类别:
This work was supported by Science and Technology Project of Guizhou Province ([2020]1Y138); Guizhou High-level innovative Talents Training Project (Thousand level innovative talents)(2022- (2020) -044); Doctoral Talents project of Science and Technology Bureau of Tongren, Guizhou Province ([2020]126); Key laboratory project of Guizhou Province ([2020]2003) and the science and technology supporting project of Science and Technology Bureau of Tongren ([2020]128). We thank Pengchao Wang and Jinjia Liu for caring of the sheep at Taigu Haihong Animal Husbandry Co. LTD.
机构署名:
本校为其他机构
院系归属:
动物医学院
摘要:
N6-methyladenosine (m6A) is the most universal post-transcriptional modification of mRNA which may play important roles in verious species. However, the potential roles of m6A in the pigmentation of skin are not completely understood. To explore the role of m6A modification in pigmentation of sheep skin, we used MeRIP-seq and RNA-seq to profile the skin transcriptome in black and white coat color (n=3). Our results showed that an average of 7701 m6A peaks were obtained for all samples and the average length was 305.89 bp. The GGACUU sequence wa...

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