期刊论文

Tu, Qichao;Lin, Lu

英文

BIOINFORMATICS

1367-4803

2019

35

6

1040-1048

10.1093/bioinformatics/bty741

This study was supported by the National Natural Science Foundation of China (31700427, 41606154), by Zhejiang Provincial Natural Science Foundation of China (LQ17D060002), by the Qilu Young Scholarship of Shandong University, by the Bureau of Science and Technology of Zhoushan (2017C82218), by the Open Funding of State Key Laboratory of Applied Microbiology Southern China (SKYAM002-2016) and by the Open Project of Key Laboratory of Environmental Biotechnology, CAS (Grant No kf2016002). The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.

本校为其他机构

MOTIVATION: The nitrogen (N) cycle is a collection of important biogeochemical pathways in the Earth ecosystem and has gained extensive foci in ecology and environmental studies. Currently, shotgun metagenome sequencing has been widely applied to explore gene families responsible for N cycle processes. However, there are problems in applying publically available orthology databases to profile N cycle gene families in shotgun metagenomes, such as inefficient database searching, unspecific orthology groups and low coverage of N cycle genes and/or gene (sub)families. RESULTS: To solve these issue...