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T-2 toxin triggers depression-like behaviors via upregulation of dopamine transporter in nucleus accumbens of male mice

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成果类型:
期刊论文
作者:
Chen, Zhigang;Duan, Shaoyi;Li, Jialu;Su, Jianming;Lei, Hongyu
通讯作者:
Lei, HY
作者机构:
[Duan, Shaoyi; Chen, Zhigang; Li, Jialu; Lei, Hongyu; Lei, HY; Su, Jianming] Hunan Agr Univ, Coll Vet Med, Changsha 410125, Peoples R China.
通讯机构:
[Lei, HY ] H
Hunan Agr Univ, Coll Vet Med, Changsha 410125, Peoples R China.
语种:
英文
关键词:
T-2 toxin;Depression-like behaviors;Dopamine transporter;Ventral tegmental area;Nucleus accumbens;Chemogenetic activation
期刊:
Ecotoxicology and Environmental Safety
ISSN:
0147-6513
年:
2025
卷:
289
页码:
117392
基金类别:
Scientific Research Project of Hunan Provincial Education Department, China [19A229]; Natural Science Foundation of Hunan Province, China [2022JJ30022, 2022JJ30293]
机构署名:
本校为第一且通讯机构
院系归属:
动物医学院
摘要:
The T-2 toxin is a frequent contaminant in the global environment and agricultural production. Existing evidence suggests that the ingested T-2 toxin can enter the brain and exhibit neurotoxicity. However, it is still unknown whether T-2 toxin causes the depression-like behaviors. In this study, the mice were orally administrated with 1.5 mg/kg T-2 toxin daily for 14 d, and the depression-like behaviors were assessed by the tail suspension test (TST) and sucrose preference test (SPT). Here, the results showed that T-2 toxin exposure induced de...

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