T-cell immunoglobulin and ITIM domain in cancer immunotherapy: A focus on tumor-infiltrating regulatory T cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Tian, Xiaoyan;Ning, Qian;Yu, Jianqiang;Tang, Shengsong

通讯作者：

Jianqiang Yu

作者机构：

[Tang, Shengsong; Tian, Xiaoyan; Yu, Jianqiang] Ningxia Med Univ, Dept Pharmacol, Yinchuan 750004, Peoples R China.

[Tang, Shengsong; Tian, Xiaoyan; Ning, Qian] Hunan Univ Med, Sch Pharmaceut Sci, Hunan Prov Key Lab Antibody Based Drug & Intellige, Huaihua 418000, Peoples R China.

[Tang, Shengsong; Ning, Qian] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.

[Tang, Shengsong] Ningxia Med Univ, Sch Pharmacol, Yinchuan 750004, Peoples R China.

通讯机构：

[Jianqiang Yu] D

Department of Pharmacology, Ningxia Medical University, Yinchuan 750004, China

语种：

英文

关键词：

Cancer immunotherapy;Immune checkpoint;Regulatory T cells;TIGIT

期刊：

Molecular Immunology

ISSN：

0161-5890

年：

2022

卷：

147

页码：

62-70

DOI：

10.1016/j.molimm.2022.04.014

基金类别：

National Natural Science Foundation of China [30270684]; Hunan Provincial Science and Technology Plan Key Projects of China [2017SK2183]; Hunan Provincial Natural Science Foundation of China [2019JJ50416]; Scientific Research Fund of Hunan Provincial Education Department [18C1133]; Scientific Research Project of Hunan Provincial Health Commission [202113022028]

机构署名：

本校为其他机构

院系归属：

生物科学技术学院

摘要：

T-cell immunoglobulin and ITIM domain (TIGIT) is a novel type of immune checkpoint. Importantly, immune checkpoint molecules promote cancer progression by various antitumor suppressive mechanisms. TIGIT is an inhibitory receptor expressed on T cells, natural killer cells, and regulatory T cells that was recently attracted attention as a major emerging target for cancer immunotherapy. Regulatory T cells (Tregs) play crucial roles in immune homeostasis. Specifically, tumor-infiltrating Tregs promote cancer progression by restricting antitumor immunity and supporting tumor immune escape. In this ...

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T-cell immunoglobulin and ITIM domain in cancer immunotherapy: A focus on tumor-infiltrating regulatory T cells

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