期刊论文

Zhihang Yuan

英文

Foods

2304-8158

2023

12

8

1616-

10.3390/foods12081616

Conceptualization, J.W.; methodology, Y.W., C.Y. and M.Y.; software, H.F. and X.K.; validation, C.N. and S.W.; formal analysis, W.X. and Z.Y.; resources, N.W.; data curation, C.Y. and Y.W.; writing—original draft preparation, Y.W. and C.Y.; writing—review and editing, C.Y. and J.W.; project administration, J.W.; funding acquisition, J.W. and J.Y. All authors have read and agreed to the published version of the manuscript. This work was supported by the Natural Science Foundation of Hunan province (2021JJ30343 and 2020JJ4368); The Special Funds for Construction of Innovative Provinces in Hunan Province (2020NK2032); Innovation Research and Development Project of Hunan Development and Reform Commission (Grant No. 37).

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Damage to the reproductive system is the key factor leading to male infertility. Citrinin (CTN) is produced by Penicillium and Aspergillus in nature, and is definitely found in food and animal feed. Studies have revealed that CTN can cause damage to male reproductive organs and reduce fertility, but the mechanism of toxicity has not been revealed. In the present study, male Kunming mice were given different doses of CTN (0, 1.25, 5 or 20 mg/kg BW) by intragastric administration. The results demonstrated that CTN exposure caused disorder of androgen, a decline in sperm quality, and histopatholo...