The nonproton ligand of acid-sensing ion channel 3 activates mollusk-specific FaNaC channels via a mechanism independent of the native FMRFamide peptide

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成果类型：

期刊论文

作者：

Yang, Xiao-Na;Niu, You-Ya;Liu, Yan;Yang, Yang;Wang, Jin;...

通讯作者：

Tian, Yun;Yu, Ye

作者机构：

[Tian, Yun; Zhu, Michael X.; Niu, You-Ya; Lu, Xiang-Yang; Yu, Ye; Yang, Xiao-Na; Tian, Y] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.

[Niu, You-Ya; Hu, You-Min; Yang, Yang; Liu, Yan; Yu, Ye; Wang, Jin; Yang, Xiao-Na] Shanghai Jiao Tong Univ, Sch Med, Inst Med Sci, Shanghai 200025, Peoples R China.

[Niu, You-Ya; Hu, You-Min; Yang, Yang; Liu, Yan; Yu, Ye; Wang, Jin; Yang, Xiao-Na] Shanghai Jiao Tong Univ, Sch Med, Dept Pharmacol & Chem Biol, Shanghai 200025, Peoples R China.

[Niu, You-Ya] Hunan Univ Med, Dept Cell Biol & Genet, Huaihua 418000, Peoples R China.

[Xu, Tian-Le; Cheng, Xiao-Yang] Shanghai Jiao Tong Univ, Dept Anat Histol & Embryol, Discipline Neurosci, Sch Med, Shanghai 200025, Peoples R China.

通讯机构：

[Tian, Y; Yu, Y] H

[Yu, Ye] S

Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.

Shanghai Jiao Tong Univ, Sch Med, Inst Med Sci, Shanghai 200025, Peoples R China.

Shanghai Jiao Tong Univ, Sch Med, Dept Pharmacol & Chem Biol, Shanghai 200025, Peoples R China.

语种：

英文

关键词：

*2-guanidine-4-methylquinazoline (GMQ);*FMRFamide (Phe-Met-Arg-Phe-NH2) peptides;*FMRFamide peptide-gated sodium channel (FaNaC);*acid-sensing ion channels (ASIC);*epithelial sodium channel (ENaC);*ion channel;*ligand-binding protein;*neuropeptide;*small molecule

期刊：

Journal of Biological Chemistry

ISSN：

0021-9258

年：

2017

卷：

292

期：

页码：

21662-21675

DOI：

10.1074/jbc.M117.814707

基金类别：

National Program on Key Basic Research Project of ChinaNational Basic Research Program of China [2014CB910300/02]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31570832, 21431001, 31170787, 81760626, 31400707]; Guangxi Foundation for Distinguished Experts; National Excellent Young Scientist Foundation of China [31222018]; Innovation Program of Shanghai Municipal Education CommissionInnovation Program of Shanghai Municipal Education Commission [14YZ034]; Research Foundation of Education Bureau of Hunan Province, China [17A153]

机构署名：

本校为第一且通讯机构

院系归属：

生物科学技术学院

摘要：

The degenerin/epithelial sodium channel (DEG/ENaC) superfamily of ion channels contains subfamilies with diverse functions that are fundamental to many physiological and pathological processes, ranging from synaptic transmission to epileptogenesis. The absence in mammals of some DEG/ENaCs subfamily orthologues such as FMRFamide peptide-activated sodium channels (FaNaCs), which have been identified only in mollusks, indicates that the various subfamilies diverged early in evolution. We recently reported that the nonproton agonist 2-guanidine-4-methylquinazoline (GMQ) activates acid-sensing ion ...

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The nonproton ligand of acid-sensing ion channel 3 activates mollusk-specific FaNaC channels via a mechanism independent of the native FMRFamide peptide

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