Aging-Accelerated Mouse Prone 8 (SAMP8) Mice Experiment and Network Pharmacological Analysis of Aged Liupao Tea Aqueous Extract in Delaying the Decline Changes of the Body

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成果类型：

期刊论文

作者：

Pan, Wenjing;Li, Wangshu;Wu, Huan;Xie, Xinya;Xie, Mingwei;...

通讯作者：

Shuxian Cai<&wdkj&>Zhonghua Liu

作者机构：

[Xie, Xinya; Wu, Huan; Xie, Mingwei; Nie, Qing; Liu, Zhonghua; Cai, Shuxian; Li, Wangshu; Pan, Wenjing] Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Bot Funct Ingre, Changsha 410128, Peoples R China.

[Xie, Xinya; Wu, Huan; Xie, Mingwei; Nie, Qing; Liu, Zhonghua; Cai, Shuxian; Li, Wangshu; Pan, Wenjing] Hunan Agr Univ, Key Lab Minist Educ Tea Sci, Changsha 410128, Peoples R China.

[Xie, Xinya; Wu, Huan; Xie, Mingwei; Nie, Qing; Liu, Zhonghua; Cai, Shuxian; Li, Wangshu; Pan, Wenjing] Hunan Agr Univ, Coinnovat Ctr Educ Minist Utilizat Bot Funct Ingre, Changsha 410128, Peoples R China.

[Xie, Xinya; Wu, Huan; Xie, Mingwei; Nie, Qing; Liu, Zhonghua; Cai, Shuxian; Li, Wangshu; Pan, Wenjing] Hunan Agr Univ, Key Lab Evaluat & Utilizat Gene Resources Hort Cro, Minist Agr & Rural Affairs China, Changsha 410128, Peoples R China.

[Pan, Wenjing] Wuzhou Inst Agr, Wuzhou 543003, Peoples R China.

通讯机构：

[Shuxian Cai; Zhonghua Liu] A

Authors to whom correspondence should be addressed.<&wdkj&>Key Laboratory of Ministry of Education for Tea Science, Hunan Agricultural University, Changsha 410128, China<&wdkj&>National Research Center of Engineering Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, China<&wdkj&>Co-Innovation Center of Education Ministry for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, China<&wdkj&>Key Laboratory for Evaluation and Utilization of Gene Resources of Horticultural Crops, Ministry of Agriculture and Rural Affairs of China, Hunan Agricultural University, Changsha 410128, China

语种：

英文

关键词：

aged Liupao tea;aging-accelerated mouse prone 8 (SAMP8) mice;degenerative changes;network pharmacology;molecular docking

期刊：

Antioxidants

ISSN：

2076-3921

年：

2023

卷：

期：

页码：

685-

DOI：

10.3390/antiox12030685

基金类别：

Experiments, data curation and writing the original draft, W.P.; investigation and visualization, W.L., H.W., X.X., M.X. and Q.N.; writing—review, S.C.; funding acquisition, resources and supervision, Z.L. and S.C. All authors have read and agreed to the published version of the manuscript. This research was funded by the Guangxi Innovation Driven Development Special Fund Project (No. AA20302018), the National Key R&D Program of China (2018YFC1604405), the Key R&D Program of Hunan Province (2020WK2017), National Tea Industry Technology System Research Project of China (CARS-19-C01), National Natural Science Foundation Project of China (31471590, 31100501) and Self-Science Foundation of Hunan Province, China (2019jj50237).

机构署名：

本校为第一机构

院系归属：

园艺园林学院

摘要：

Aging and metabolic disorders feedback and promote each other and are closely related to the occurrence and development of cardiovascular disease, type 2 diabetes, neurodegeneration and other degenerative diseases. Liupao tea is a geographical indication product of Chinese dark tea, with a “red, concentrated, aged and mellow” flavor quality. In this study, the aqueous extract of aged Liupao tea (ALPT) administered by continuous gavage significantly inhibited the increase of visceral fat and damage to the intestinal–liver–microbial axis in h...

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Aging-Accelerated Mouse Prone 8 (SAMP8) Mice Experiment and Network Pharmacological Analysis of Aged Liupao Tea Aqueous Extract in Delaying the Decline Changes of the Body

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