期刊论文

Yuan, XM

英文

Vaccine

0264-410X

2025

54

127093

10.1016/j.vaccine.2025.127093

Authors' Contribution XY conceived and designed the experiments, provided funding, and revised the manuscript. FZ conducted the experiments, collected data, and drafted the initial manuscript. MZ and HR conducted the experiments and analyzed the data. SF and BB oversaw resource allocation. WD and BL managed the experimental data, LW and JH revised the manuscript. All authors contributed to the review and revision of this manuscript, and approved it for publication. information This work was supported by Hunan Provincial Department of Education Scientific Research Project (22B0224), the Science and Technology Major Project of Yunnan Province ( 202202AE090032 ), Open project of Key Laboratory of Veterinary biological Products Engineering Technology of Ministry of Agriculture and Rural Affairs (SYKF(23)002).

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Pseudorabies virus (PRV) causes high mortality encephalitis in newborn piglets, abortion and stillbirth in sows, resulting in huge economic losses to the swine industry. Interferon-induced transmembrane proteins (IFITMs) play a crucial role in the innate immune response triggered by viral infection. Lactic acid bacteria (LABs) are good candidates for the development of new oral vaccines and are attractive alternatives to attenuated pathogens. “Here we tested the capacity of a LAB vector expressing the IFITM3 protein (r-LAB-I3), delivered by or...