期刊论文

中文

中国实验动物学报

1005-4847

2009

17

2

90-96

10.3969/j.issn.1005-4847.2009.02.003

30671516:国家自然科学基金 30170684:国家自然科学基金

本校为第一机构

目的 筛选出小鼠肝脏金属硫蛋白(MT)合成量最大的诱导方式.方法 从时间-效应和剂量-效应两方面研究了重金属元素(Cd)、微量元素(Zn)、重金属与微量元素的组合(Cd+Zn)、生理因子(饥饿)及创伤因子等五大类组合应激因子、19种诱导方式对小鼠肝脏中MT诱导合成的影响及效果.结果 生理因子诱导MT量最小,饥饿诱导小鼠肝脏MT的量随饥饿程度的加重而增加,但各组间差异不显著(P>0.05);创伤因子诱导产生MT的量最高,其诱导量随创伤恢复时间的增加而降低,各组之间差异显著(P

Objective To developan optimal treating way to induce the most production of metallothionein in mouse liver.Methods Trauma,starvation,zinc（Zn）,cadmium（Cd）,Zn-Cd mixture,all together five kinds of stress factors and 19 treating ways,were used as inducers to enhance the production of metallothionein in Kunming mouse liver,designed according to the duration-effect and dose-effect relationship.Results The production of metallothionein induced by starvation was the least among all inducers,the longer the mouse-hungry time the higher production o...