Effects of Prevotella copri on insulin, gut microbiota and bile acids

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Gong, Jiatai;Zhang, Qianjin;Hu, Ruizhi;Yang, Xizi;Fang, Chengkun;...

通讯作者：

Wu, SS;Peng, LJ

作者机构：

[Ma, Siqi; Lv, Jing; Yao, Liping; Zhang, Qianjin; Xiang, Hongkun; Hou, De-Xing; Fang, Chengkun; Zhang, Wentao; Zhang, Hongfu; Yin, Yulong; Yang, Xizi; He, Jianhua; Wu, Shusong; Hu, Ruizhi; Wang, Long; Gong, Jiatai; Shi, Mingkun] Hunan Agr Univ, Coll Anim Sci & Technol, Hunan Collaborat Innovat Ctr Utilizat Bot Funct In, Changsha, Peoples R China.

[Zhang, Hongfu] Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr, Beijing, Peoples R China.

[Hou, De-Xing] Kagoshima Univ, Fac Agr, Dept Food Sci & Biotechnol, Korimoto, Kagoshima, Japan.

[Peng, Lijun] Cent South Univ, Affiliated Childrens Hosp, Hunan Childrens Hosp, Childrens Healthcare Inst, Changsha 410007, Hunan, Peoples R China.

通讯机构：

[Peng, LJ ] C

[Wu, SS ] H

Hunan Agr Univ, Coll Anim Sci & Technol, Hunan Collaborat Innovat Ctr Utilizat Bot Funct In, Changsha, Peoples R China.

Cent South Univ, Affiliated Childrens Hosp, Hunan Childrens Hosp, Childrens Healthcare Inst, Changsha 410007, Hunan, Peoples R China.

语种：

英文

关键词：

Obesity;prevotella copri;insulin;gut microbiota;bile acids

期刊：

Gut Microbes

ISSN：

1949-0976

年：

2024

卷：

期：

DOI：

10.1080/19490976.2024.2340487

基金类别：

National Natural Science Foundation of China#&#&#32102578 National Key R&D Program of China#&#&#2023YFD1302300#&#&#2023YFD1301200 Changsha Natural Science Foundation#&#&#kq2208092 Hunan Provincial Health Commission#&#&#C202306017634

机构署名：

本校为第一且通讯机构

院系归属：

动物科学技术学院

摘要：

Obesity is becoming a major global health problem in children that can cause diseases such as type 2 diabetes and metabolic disorders, which are closely related to the gut microbiota. However, the underlying mechanism remains unclear. In this study, a significant positive correlation was observed between Prevotella copri (P. copri) and obesity in children (p = 0.003). Next, the effect of P. copri on obesity was explored by using fecal microbiota transplantation (FMT) experiment. Transplantation of P. copri. increased serum levels of fasting blood glucose (p < 0.01), insulin (p < 0.01) and inte...

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Effects of Prevotella copri on insulin, gut microbiota and bile acids

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