期刊论文

Yang, LC

英文

TOXINS

2072-6651

2023

15

8

503-

10.3390/toxins15080503

Author Contributions: Conceptualization, L.Y. and Y.W.; Methodology, L.Y., S.G.; Software, S.X.; Validation, S.X. and Y.W.; Formal analysis, Y.W. and S.G; Investigation, Y.W. and M.Z.; Resources, L.Y; Data curation, S.X. and Z.L.; Writing—original draft preparation, S.X. and Q.X.; Writing—review and editing, L.Y., L.J., G.Y. and L.L.; Visualization, Y.W.; Supervision, L.Y.; Project administration, L.Y.; Funding acquisition, L.Y. All authors have read and agreed to the published version of the manuscript. This work was supported by: Program of National Natural Science Foundation of China (Grants No. 31802252); Scientific Research Fund of the Hunan Provincial Education Department (Grants No. 21A0144); Hunan Provincial Natural Science Foundation of China (Grant No. 2022JJ40182).

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In China, animal feeds are frequently contaminated with a range of mycotoxins, with Aflatoxin B1 (AFB1) and T-2 toxin (T-2) being two highly toxic mycotoxins. This study investigates the combined nephrotoxicity of AFB1 and T-2 on PK15 cells and murine renal tissues and their related oxidative stress mechanisms. PK15 cells were treated with the respective toxin concentrations for 24 h, and oxidative stress-related indicators were assessed. The results showed that the combination of AFB1 and T-2 led to more severe cellular damage and oxidative stress compared to exposure to the individual toxins...