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FZD7, Regulated by Non-CpG Methylation, Plays an Important Role in Immature Porcine Sertoli Cell Proliferation

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成果类型:
期刊论文
作者:
Yang, Anqi;Yan, Saina;Yin, Yanfei;Chen, Chujie;Tang, Xiangwei;...
通讯作者:
Maoliang Ran<&wdkj&>Bin Chen
作者机构:
[Yan, Saina; Chen, Chujie; Tang, Xiangwei; Yin, Yanfei; Ran, Maoliang; Yang, Anqi; Chen, Bin] Hunan Agr Univ, Coll Anim Sci & Technol, Hunan Prov Key Lab Genet Improvement Domest Anim, Changsha 410128, Peoples R China.
通讯机构:
[Maoliang Ran; Bin Chen] C
College of Animal Science and Technology, Hunan Provincial Key Laboratory for Genetic Improvement of Domestic Animal, Hunan Agricultural University, Changsha 410128, China<&wdkj&>Authors to whom correspondence should be addressed.
语种:
英文
关键词:
adenosine triphosphate;calcium ion;messenger RNA;Myc protein;platelet endothelial cell adhesion molecule 1;prostaglandin E2;small interfering RNA;vasculotropin A;zebularine;guanine nucleotide exchange factor;hydrogen sulfite;sulfite;animal cell;animal tissue;apoptosis;Article;cell proliferation;controlled study;developmental stage;DNA demethylation;DNA methylation;down regulation;exon;fzd7 gene;G2 phase cell cycle checkpoint;gene;gene expression;gene expression regulation;gene silencing;genetic transfection;male;mRNA expression level;newborn;nonhuman;pig;protein expression;regulatory mechanism;RNA interference;RNA sequencing;Sertoli cell;somatic cell;testis development;testis tissue;whole genome bisulfite sequencing;animal;cell proliferation;CpG island;genetics;mammal;Animals;Cell Proliferation;CpG Islands;DNA Methylation;Guanine Nucleotide Exchange Factors;Male;Mammals;Sulfites;Swine
期刊:
International Journal of Molecular Sciences
ISSN:
1661-6596
年:
2023
卷:
24
期:
7
页码:
6179-
基金类别:
This work was financially supported by key R&D projects in Hunan Province (2020NK2024), an earmarked fund for the Hunan Provincial Agriculture Research System, and the Hunan Provincial Natural Science Foundation of China (2020JJ4348). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
机构署名:
本校为第一机构
院系归属:
动物科学技术学院
摘要:
The regulatory role of non-CpG methylation in mammals has been important in whole-genome bisulfite sequencing. It has also been suggested that non-CpG methylation regulates gene expression to affect the development and health of mammals. However, the dynamic regulatory mechanisms of genome-wide, non-CpG methylation during testicular development still require intensive study. In this study, we analyzed the dataset from the whole-genome bisulfite sequencing (WGBS) and the RNA-seq of precocious porcine testicular tissues across two developmental s...

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