Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

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成果类型：

期刊论文

作者：

Zhang, Baozhen;Chen, Zhilong;Han, Jinyu;Li, Mengxia;Nayak, Nihar R.;...

通讯作者：

Fan, Xiujun

作者机构：

[Zhang, Baozhen; Han, Jinyu; Li, Mengxia; Fan, Xiujun; Chen, Zhilong] Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Lab Reprod Hlth, Beijing, Peoples R China.

[Chen, Zhilong] Hunan Agr Univ, Coll Vet Med, Changsha, Hunan, Peoples R China.

[Han, Jinyu] Heilongjiang Univ, Coll Chem & Mat Sci, Key Lab Chem Engn Proc & Technol High Efficiency, Harbin, Heilongjiang, Peoples R China.

[Nayak, Nihar R.] Wayne State Univ, Sch Med, Dept Obstet & Gynecol, Detroit, MI 48202 USA.

通讯机构：

[Fan, Xiujun] C

Chinese Acad Sci, Shenzhen Inst Adv Technol, Inst Biomed & Biotechnol, Lab Reprod Hlth, Beijing, Peoples R China.

语种：

英文

关键词：

Bioengineering;High-frequency ultrasound;High-performance liquid chromatography;In vivo imaging;Issue 139;Nanoparticles;Placenta targeting;Placental chondroitin sulfate a binding peptide;Pregnancy complications

期刊：

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

ISSN：

1940-087X

年：

2018

卷：

2018

期：

139

DOI：

10.3791/58219

基金类别：

National Natural Sciences FoundationNational Natural Science Foundation of China (NSFC) [81771617]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2016A030313178]; Shenzhen Basic Research Fund [JCYJ20170413165233512]; Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health [R01HD088549]; EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENTUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) [R01HD088549, R01HD088549, R01HD088549, R01HD088549, R01HD088549] Funding Source: NIH RePORTER

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本校为其他机构

院系归属：

动物医学院

摘要：

No effective treatments currently exist for placenta-associated pregnancy complications, and developing strategies for the targeted delivery of drugs to the placenta while minimizing fetal and maternal side effects remains challenging. Targeted nanoparticle carriers provide new opportunities to treat placental disorders. We recently demonstrated that a synthetic placental chondroitin sulfate A binding peptide (plCSA-BP) could be used to guide nanoparticles to deliver drugs to the placenta. In this protocol, we describe in detail a system for as...

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Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

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