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Integrative Multiomics Analysis of the Heat Stress Response of Enterococcus faecium

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成果类型:
期刊论文
作者:
Wang, Li;Qiao, Lin;Li, Aike;Chen, Lixian;He, Beibei;...
通讯作者:
Wang, W.;Fang, J.
作者机构:
[Liu, Gang; Wang, Li; Fang, Jun] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.
[He, Beibei; Wang, Li; Qiao, Lin; Wang, Weiwei; Li, Aike; Chen, Lixian] Strateg Reserv Adm, Acad Natl Food, Beijing 100037, Peoples R China.
通讯机构:
[Jun Fang; Weiwei Wang] A
Authors to whom correspondence should be addressed.<&wdkj&>Academy of National Food and Strategic Reserves Administration, Beijing 100037, China<&wdkj&>Authors to whom correspondence should be addressed.<&wdkj&>College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China
语种:
英文
关键词:
Enterococcus faecium;heat-adaptation;transcriptomic;metabolomic
期刊:
Biomolecules
ISSN:
2218-273X
年:
2023
卷:
13
期:
3
页码:
437-
基金类别:
Conceptualization, L.W., L.Q. and A.L.; methodology, L.W., L.Q. and A.L.; formal analysis, L.W., L.C., B.H. and G.L.; investigation, L.W.; resources, L.W.; data curation, L.W.; writing—original draft preparation, L.W.; writing—review and editing, W.W.; visualization, L.W.; supervision, L.Q.; project administration, J.F.; funding acquisition, L.W. All authors have read and agreed to the published version of the manuscript. This research was funded by the Special Fund of the Chinese Central Government for Basic Scientific Research Operations in Commonweal Research Institutes, grant number JY2201.
机构署名:
本校为第一机构
院系归属:
生物科学技术学院
摘要:
A continuous heat-adaptation test was conducted for one Enterococcus faecium (E. faecium) strain wild-type (WT) RS047 to obtain a high-temperature-resistant strain. After domestication, the strain was screened with a significantly higher ability of heat resistance. which is named RS047-wl. Then a multi-omics analysis of transcriptomics and metabolomics was used to analyze the mechanism of the heat resistance of the mutant. A total of 98 differentially expressed genes (DEGs) and 115 differential metabolites covering multiple metabolic processes were detected in the mutant, which indicated that ...

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