期刊论文

Liu, Gang;Fang, J

英文

International Journal of Molecular Sciences

1661-6596

2023

24

19

14991-

10.3390/ijms241914991

Writing—original draft preparation, Y.F.; writing—review and editing, Y.F., S.L., Y.X., J.F. and G.L.; supervision, J.F. and G.L.; funding acquisition, J.F. and G.L. All authors have read and agreed to the published version of the manuscript. This study was supported by the Hunan Provincial Science and Technology Department (2021JJ30008, 2020NK2004, 2019TP2004, 2021JJ30320), Double first-class construction project of Hunan Agricultural University (SYL201802003), Postgraduate Scientific Research Innovation Project of Hunan Province (CX20210654), Science and Technology Innovation and Entrepreneurship Project for University Students of Hunan Province (2021RC1004), and Hunan Provincial Innovation and Entrepreneurship Training Program for College Students (S202310537034).

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Type 2 diabetes (T2D) is a commonly diagnosed condition that has been extensively studied. The composition and activity of gut microbes, as well as the metabolites they produce (such as short-chain fatty acids, lipopolysaccharides, trimethylamine N-oxide, and bile acids) can significantly impact diabetes development. Treatment options, including medication, can enhance the gut microbiome and its metabolites, and even reverse intestinal epithelial dysfunction. Both animal and human studies have demonstrated the role of microbiota metabolites in influencing diabetes, as well as their complex che...